MARCKSL1 Human

MARCKSL1 is a 20 kDa protein that binds to F-actin, Ca²⁺/calmodulin, and acidic phospholipids . It plays a crucial role in the coordination of membrane-cytoskeletal signaling events, which are essential for various cellular functions such as secretion, migration, phagocytosis, and cell adhesion . The protein is expressed in a variety of tissues, with the highest levels found in the testis and uterus .

MARCKSL1 is widely expressed throughout vertebrate development, particularly in tissues derived from all germ layers, with strong expression in the nervous system . It has been implicated in the regulation of several developmental processes, including gastrulation, myogenesis, brain development, and other developmental events . Mice with loss-of-function mutations in the Marcksl1 gene exhibit multiple deficiencies, including detrimental neural tube closure defects, leading to death shortly after birth .

In adult vertebrates, MARCKSL1 continues to play a vital role in regenerative processes, including peripheral nerve, appendage, and tail regeneration . This makes MARCKSL1 a promising target for regenerative medicine.

MARCKSL1 has been identified as a key player in various pathophysiological conditions. Dysregulated expression of MARCKSL1 is associated with the development and progression of certain diseases, including hematological malignancies . The protein’s ability to modulate cytoskeletal reorganization, membrane trafficking, cell secretion, inflammatory response, cell migration, and mitosis makes it a critical regulatory node in several signaling networks .

Given its involvement in multiple cellular processes and disease states, MARCKSL1 is considered a valuable therapeutic target. Understanding the molecular interactions and cellular functions of MARCKSL1 can provide insights into novel therapeutic strategies for diseases where this protein plays a significant role .