MAPK13 Human
Mitogen-Activated Protein Kinase 13 Human Recombinant
Cat. No.
BT11153
Source
E.coli.
Synonyms
Mitogen-activated protein kinase 13, PRKM13, SAPK4, p38delta, Mitogen-activated protein kinase p38 delta, Stress-activated protein kinase 4, MAP kinase 13, MAP kinase p38 delta, EC 2.7.11.24.
Appearance
Sterile Filtered colorless solution.
Purity
Greater than 90% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description
MAPK13 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 385 amino acids (1-365) and having a molecular mass of 44.2 kDa.
MAPK13 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
MAPK13 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Introduction
MAPK13, a member of the MAP kinase family, serves as a convergence point for diverse biochemical signals. It plays a crucial role in various cellular processes, including differentiation, development, transcription regulation, and proliferation. MKK6 phosphorylates MAPK13 in response to cytokines and cellular stresses.
Description
Recombinant human MAPK13, produced in E.coli, is a single, non-glycosylated polypeptide chain consisting of 385 amino acids (residues 1-365) with a molecular weight of 44.2 kDa. It includes a 20 amino acid His-tag fused at the N-terminus. Purification is achieved through proprietary chromatographic techniques.
Physical Appearance
Clear, colorless solution, sterile-filtered.
Formulation
The MAPK13 solution is provided at a concentration of 1mg/ml in a buffer consisting of 20mM Tris-HCl (pH 8.0), 0.1M NaCl, 1mM DTT, and 20% glycerol.
Stability
For short-term storage (2-4 weeks), store at 4°C. For extended storage, freeze at -20°C. Adding a carrier protein (0.1% HSA or BSA) is recommended for long-term storage. Avoid repeated freeze-thaw cycles.
Purity
Purity is determined to be greater than 90% by SDS-PAGE analysis.
Synonyms
Mitogen-activated protein kinase 13, PRKM13, SAPK4, p38delta, Mitogen-activated protein kinase p38 delta, Stress-activated protein kinase 4, MAP kinase 13, MAP kinase p38 delta, EC 2.7.11.24.
Source
E.coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MSLIRKKGFY KQDVNKTAWE LPKTYVSPTH VGSGAYGSVC SAIDKRSGEK VAIKKLSRPF QSEIFAKRAY RELLLLKHMQ HENVIGLLDV FTPASSLRNF YDFYLVMPFM QTDLQKIMGM EFSEEKIQYL VYQMLKGLKY IHSAGVVHRD LKPGNLAVNE DCELKILDFG LARHADAEMT GYVVTRWYRA PEVILSWMHY NQTVDIWSVG CIMAEMLTGK TLFKGKDYLD QLTQILKVTG VPGTEFVQKL NDKAAKSYIQ SLPQTPRKDF TQLFPRASPQ AADLLEKMLE LDVDKRLTAA QALTHPFFEP FRDPEEETEA QQPFDDSLEH EKLTVDEWKQ HIYKEIVNFS PIARKDSRRR SGMKL.
Product Science Overview
Gene and Protein Information
MAPK13 is encoded by the MAPK13 gene, located on chromosome 6p21.31 in humans . The gene produces a serine/threonine kinase, which is an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs, which are activated by extracellular stimuli such as pro-inflammatory cytokines or physical stress .
Function and Mechanism
MAPK13 acts as an integration point for multiple biochemical signals. It is activated by pro-inflammatory cytokines and cellular stress, leading to the activation of transcription factors such as ELK1 and ATF2 . The substrates of MAPK13 include the transcription factor ATF2 and the microtubule dynamics regulator stathmin .
Clinical Relevance
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