Malaria Pf. MSP1
Protein is >90% pure as determined by 10% PAGE (coomassie staining).
Description
Merozoite surface antigen is a protein located on the outside of the merozoite, playing an imperative role in immune reaction. About 55% cases of malaria are infected by Plasmodium falciparum (Pf). Pf MSP1 has to be used with Plasmodium vivax (Pv) together for ELISA and rapid diagnostic test, Plasmodium falciparum and vivax infection takes about 95% of Plasmodium caused infection.
Recombinant Malaria Falciparum MSP1 produced in E.coli, is a 62kDa protein fused to a GST tag at N-terminus and purified by proprietary chromatographic technique.
Product Specs
Product Science Overview
Malaria remains a significant global health challenge, with Plasmodium falciparum being the most deadly of the malaria parasites. One of the key proteins involved in the malaria parasite’s life cycle is the Merozoite Surface Protein 1 (MSP1). This protein plays a crucial role in the invasion of red blood cells by the merozoite stage of the parasite. The recombinant form of MSP1 has been extensively studied for its potential as a vaccine candidate.
MSP1 is a large protein that is initially synthesized as a precursor and then processed into several fragments. The most notable fragment is MSP1-19, a 19 kDa C-terminal region that remains on the merozoite surface during red blood cell invasion. This fragment is highly conserved and is considered a prime target for immune responses .
Research has shown that antibodies targeting MSP1, particularly MSP1-19, can inhibit the growth of the parasite and provide protective immunity. Studies have demonstrated that MSP1-specific antibodies can mediate various immune functions, including complement fixation, phagocytosis, and natural killer cell activity . These findings underscore the potential of MSP1 as a vaccine candidate.
Recombinant MSP1 is produced using genetic engineering techniques to express the protein in various host systems, such as bacteria, yeast, or mammalian cells. This recombinant form is used in research to study the protein’s structure, function, and immunogenicity. It is also a key component in the development of malaria vaccines.
Several clinical trials have been conducted to evaluate the safety and immunogenicity of MSP1-based vaccines. These trials have shown promising results, with MSP1 vaccines inducing strong antibody responses in humans . However, the efficacy of these vaccines in providing long-term protection against malaria remains an area of active research.
