LRP2BP Human

LRP2 is an approximately 600 kDa protein composed of 4665 amino acids . It shares structural similarities with the low-density lipoprotein receptor (LDLR) and contains an NPXY motif that serves as a binding site for Dab2, initiating clathrin-mediated endocytosis . LRP2 forms a homodimer that changes conformation in response to pH, allowing it to bind ligands at extracellular pH and release them at acidic endosomal pH .

LRP2 is predominantly expressed in the epithelial cells of the proximal tubule in the kidney, where it mediates the reabsorption of filtered proteins . It is also found in other tissues, including the thyroid, where it serves as a receptor for thyroglobulin . The protein is localized to the plasma membrane and is involved in the endocytic pathway, recycling receptors back to the apical surface after internalization .

Mutations in the LRP2 gene are associated with several diseases, including Donnai-Barrow Syndrome and Stickler Syndrome . The protein’s role in endocytosis and ligand binding makes it a potential target for drug development and therapeutic interventions .

Recombinant LRP2 is produced using recombinant DNA technology, which involves inserting the LRP2 gene into a suitable expression system to produce the protein in vitro. This recombinant protein is used in various research applications to study its function, interactions, and potential therapeutic uses.