LMO1 Human

LIM Domain Only 1 (LMO1) is a member of the LIM-only (LMO) family of genes, which encode transcriptional cofactors. These cofactors play a crucial role in regulating gene transcription by acting as key connectors or scaffolds in transcription complexes . The LMO family consists of four members: LMO1, LMO2, LMO3, and LMO4 .

The LMO1 gene is located on human chromosome 11p15.4 and is also known as T-cell translocation gene 1 (TTG-1) or rhombotin . The LMO1 protein is characterized by the presence of LIM domains, which are specialized zinc-binding domains that mediate protein-protein interactions . The human recombinant LMO1 protein is typically produced in Escherichia coli (E. coli) and consists of 179 amino acids, with a molecular mass of approximately 20.2 kDa .

LMO1 functions as a transcriptional cofactor, meaning it does not directly bind to DNA but instead interacts with other transcription factors to regulate gene expression . This protein is involved in various biological processes, including cell differentiation, development, and tumorigenesis . LMO1 has been shown to play a critical oncogenic role in several types of cancers, such as T-cell acute lymphoblastic leukemia, neuroblastoma, gastric cancer, lung cancer, and prostate cancer .

The oncogenic activity of LMO1 is primarily attributed to its ability to form transcriptional complexes with other proteins, thereby influencing the expression of genes involved in cell proliferation and survival . The molecular mechanisms underlying LMO1’s functions are complex and not fully understood, but they involve interactions with various transcription factors and co-regulators .

Given its role in tumorigenesis, LMO1 is a potential target for cancer diagnosis and therapy . Understanding the mechanisms that drive its aberrant activation in cancers could lead to the development of novel therapeutic strategies. Additionally, LMO1’s involvement in non-cancer diseases and developmental processes highlights its broader significance in human biology .