LGALS14 Human

Galectin-14 Human Recombinant
Cat. No.
BT10307
Source
Escherichia Coli.
Synonyms
Placental protein 13-like, Charcot-Leyden crystal protein 2, CLC2, Galectin-14, Gal-14, LGALS14, PPL13, MGC22235.
Appearance
Sterile Filtered colorless solution.
Purity
Greater than 90.0% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description

LGALS14 Human Recombinant fused with a 23 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 162 amino acids (1-139 a.a.) and having a molecular mass of 18.5kDa. The LGALS14 is purified by proprietary chromatographic techniques.

Product Specs

Introduction
Galectin-14, also known as LGALS14, belongs to the galectin family, which are proteins that bind to carbohydrates. Galectins possess one or two carbohydrate recognition domains that enable them to bind to beta-galactoside. LGALS14 expression is primarily observed in the placenta. It is found within placental cells and eosinophils, and eosinophils release LGALS14 upon encountering allergens. LGALS14 might play a role in the development of inflammation triggered by allergies.
Description
Recombinant human LGALS14, expressed in E. coli, is a single, non-glycosylated polypeptide chain. It consists of 162 amino acids, including a 23 amino acid His tag attached to the N-terminus (1-139 a.a.), and has a molecular weight of 18.5 kDa. Purification of LGALS14 is achieved using proprietary chromatographic methods.
Physical Appearance
A clear, colorless solution that has been sterilized by filtration.
Formulation
The LGALS14 solution is provided at a concentration of 0.5 mg/ml and contains 20mM Tris-HCl buffer at pH 8.0, 20% glycerol, 0.1M NaCl, and 1mM DTT.
Stability
For short-term storage (2-4 weeks), the solution should be kept at 4°C. For extended storage, it is recommended to freeze the solution at -20°C. Adding a carrier protein (0.1% HSA or BSA) is advisable for long-term storage. Repeated freezing and thawing should be avoided.
Purity
The purity of the product is greater than 90.0%, as assessed by SDS-PAGE analysis.
Synonyms
Placental protein 13-like, Charcot-Leyden crystal protein 2, CLC2, Galectin-14, Gal-14, LGALS14, PPL13, MGC22235.
Source
Escherichia Coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSMSSLPVP YTLPVSLPVG SCVIITGTPI LTFVKDPQLE VNFYTGMDED SDIAFQFRLH FGHPAIMNSR VFGIWRYEEK CYYLPFEDGK PFELCIYVRH KEYKVMVNGQ RIYNFAHRFP PASVKMLQVL RDISLTRVLI SD.

Product Science Overview

Expression and Localization

Galectin-14, also known as LGALS14, is primarily expressed intracellularly in the placenta and eosinophils . Eosinophils are a type of white blood cell involved in the body’s immune response, particularly in combating parasitic infections and in allergic reactions. Upon allergen stimulation, eosinophils release Galectin-14 .

Function and Significance

The exact biological functions of Galectin-14 are still being investigated. However, it is believed to play a role in modulating immune responses, particularly in the context of allergic reactions and inflammation . The ability of Galectin-14 to bind to β-Galactoside suggests it may be involved in cell-cell and cell-matrix interactions, which are crucial for various physiological processes .

Recombinant Galectin-14

Recombinant Galectin-14 refers to the protein produced through recombinant DNA technology, which allows for the expression of the protein in a controlled laboratory setting. This recombinant form is used in various research applications to study the protein’s structure, function, and potential therapeutic uses .

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THE BIOTEK
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