LAYN Antibody

Layilin is a type I transmembrane protein that acts as a receptor for hyaluronan. It features an extracellular C-type lectin domain and a cytoplasmic domain that interacts with the cytoskeleton . Layilin is expressed in various tissues and plays a role in cell adhesion and migration.

Recent research has highlighted the importance of Layilin in regulatory T cells (Tregs). Tregs are a subset of CD4+ T cells that play a crucial role in maintaining immune homeostasis. Layilin is preferentially and highly expressed on a subset of activated Tregs in both healthy and diseased human skin . The expression of Layilin on Tregs is induced by TCR-mediated activation in the presence of IL-2 or TGF-β .

Layilin facilitates the adhesion of Tregs in the skin, which limits their suppressive capacity. This anchoring effect on Treg dynamic motility in vivo suggests that reduced Treg motility acts to limit immune regulation in nonlymphoid organs . This unique mechanism may guide strategies to exploit this phenomenon for therapeutic benefit.

Mouse anti-human Layilin antibodies are developed for various scientific applications, including Western Blot, ELISA, Immunohistochemistry, Flow Cytometry, and Immunocytochemistry . These antibodies target Layilin in human, mouse, and rat samples and are available in polyclonal, monoclonal, and recombinant monoclonal forms .

Anti-Layilin antibodies are used in research to study the role of Layilin in cell adhesion, migration, and immune regulation. They are essential tools for investigating the molecular pathways involved in Treg function and for developing potential therapeutic strategies targeting Layilin .