KXD1 Human

KxDL Motif Containing 1 Human Recombinant

Cat. No.

BT19248

Source

Escherichia Coli.

Synonyms

C19orf50, KXDL, MST096, MSTP096, KXD1.

Appearance

Sterile Filtered clear solution.

Purity

Greater than 85.0% as determined by SDS-PAGE.

Usage

Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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Description

KXD1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 199 amino acids (1-176 a.a.) and having a molecular mass of 22.1kDa.
KXD1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Product Specs

Introduction

KxDL Motif Containing 1 (KXD1), a member of the KXD1 family, plays a role in endosomal cargo sorting. It interacts with the BLOC-1 complex, including BLOC1S1, and with DTNBP1/BLOC1S7 through its coiled-coil domain.

Description

This product is a recombinant human KXD1 protein produced in E. coli. It is a single, non-glycosylated polypeptide chain consisting of 199 amino acids (residues 1-176) with a molecular weight of 22.1 kDa. The protein includes a 23-amino acid His-tag at the N-terminus and undergoes purification using proprietary chromatographic techniques.

Physical Appearance

The product is a clear, sterile-filtered solution.

Formulation

The KXD1 protein solution (0.5 mg/ml) is formulated in a buffer containing 20 mM Tris-HCl (pH 8.0), 0.15 M NaCl, 10% glycerol, and 1 mM DTT.

Stability

For short-term storage (2-4 weeks), keep the product refrigerated at 4°C. For extended storage, freeze the product at -20°C. Adding a carrier protein like 0.1% HSA or BSA is recommended for long-term storage. Avoid repeated freeze-thaw cycles.

Purity

The purity of the protein is greater than 85%, as determined by SDS-PAGE analysis.

Synonyms

C19orf50, KXDL, MST096, MSTP096, KXD1.

Source

Escherichia Coli.

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGSMDLPDSA SRVFCGRILS MVNTDDVNAI ILAQKNMLDR FEKTNEMLLN FNNLSSARLQ QMSERFLHHT RTLVEMKRDL DSIFRRIRTL KGKLARQHPE AFSHIPEASF LEEEDEDPIP PSTTTTIATS EQSTGSCDTS PDTVSPSLSP GFEDLSHVQP GSPAINGRSQ TDDEEMTGE.

Product Science Overview

Gene and Protein Information

Gene Name: KXD1
Aliases: BORCS4, C19orf50, FLJ25480, KXDL, MGC2749
Chromosomal Location: Chromosome 19
Protein Length: 176 amino acids
Molecular Weight: Approximately 22.1 kDa

Function and Biological Role

KXD1 is involved in the biogenesis of lysosome-related organelles such as melanosomes. It interacts with other components of the BORC complex, including BLOC1S1 and DTNBP1/BLOC1S7. The BORC complex is essential for the proper positioning of lysosomes at the cell periphery, which is crucial for various cellular processes, including nutrient sensing, signaling, and autophagy.

Recombinant Human KxDL Motif Containing 1

Recombinant human KxDL Motif Containing 1 is produced using Escherichia coli (E. coli) expression systems. The recombinant protein typically includes an N-terminal His-tag for purification purposes. This protein is used in various research applications to study its function and interactions within the BORC complex.

Associated Diseases

Mutations or dysregulation of the KXD1 gene have been linked to certain diseases, including:

3-Methylglutaconic Aciduria, Type VIII
Left Ventricular Noncompaction

Research and Applications

KXD1 is a subject of ongoing research due to its role in lysosome positioning and function. Understanding its interactions and mechanisms can provide insights into lysosomal storage disorders and other related conditions.

For more detailed information, you can refer to resources like GeneCards and The Human Protein Atlas.

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KXD1 Human

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