KLRC1 Human
Sf9, Baculovirus cells.
NKG2-A/NKG2-B type II integral membrane protein isoform NKG2-A, KLRC1, Killer Cell Lectin-Like Receptor Subfamily C, Member 1, KLRC1, CD159A, NKG2, NKG2A, CD159 antigen-like family member A, NK cell receptor A, NKG2-A/B-activating NK receptor.
Greater than 90.0% as determined by SDS-PAGE.
Description
KLRC1 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 149 amino acids (94-233a.a.) and having a molecular mass of 17.1kDa.
KLRC1 is expressed with a 9 amino acids His tag at C-Terminus and purified by proprietary chromatographic techniques.
Product Specs
NKG2-A/NKG2-B type II integral membrane protein isoform NKG2-A, KLRC1, Killer Cell Lectin-Like Receptor Subfamily C, Member 1, KLRC1, CD159A, NKG2, NKG2A, CD159 antigen-like family member A, NK cell receptor A, NKG2-A/B-activating NK receptor.
Sf9, Baculovirus cells.
ADPPSTLIQR HNNSSLNTRT QKARHCGHCP EEWITYSNSC YYIGKERRTW EESLLACTSK NSSLLSIDNE EEMKFLSIIS PSSWIGVFRN SSHHPWVTMN GLAFKHEIKD SDNAELNCAV LQVNRLKSAQ CGSSIIYHCK HKLHHHHHH
Product Science Overview
Killer Cell Lectin-Like Receptor Subfamily C, Member 1 (KLRC1), also known as NKG2A, is a protein encoded by the KLRC1 gene in humans. This protein is a member of the killer cell lectin-like receptor family, which plays a crucial role in the immune system, particularly in the function of natural killer (NK) cells.
KLRC1 is a type II transmembrane protein characterized by the presence of a C-type lectin domain. It forms a heterodimeric complex with another protein, CD94 (KLRD1), which is essential for its function. This complex is involved in the recognition of MHC class I molecules, specifically HLA-E, on target cells. The interaction between KLRC1/CD94 and HLA-E inhibits the cytotoxic activity of NK cells, thereby preventing the destruction of healthy cells .
KLRC1 is predominantly expressed in NK cells and some subsets of T cells. Its expression is regulated by various cytokines and other signaling molecules that modulate the immune response. The gene encoding KLRC1 is located on chromosome 12, within a cluster of other killer cell lectin-like receptor genes .
The primary function of KLRC1 is to regulate the activity of NK cells. By interacting with HLA-E, KLRC1/CD94 inhibits the activation of NK cells, thus preventing the lysis of normal, healthy cells. This inhibitory mechanism is crucial for maintaining self-tolerance and preventing autoimmune reactions. Additionally, KLRC1 plays a role in the immune response to viral infections and tumors by modulating the activity of NK cells .
Alterations in the expression or function of KLRC1 have been associated with various diseases, including cancer and viral infections. For instance, downregulation of KLRC1 expression has been observed in certain types of cancer, which may contribute to the evasion of immune surveillance by tumor cells. Conversely, upregulation of KLRC1 expression can enhance the inhibitory signals in NK cells, potentially leading to impaired immune responses .
Given its role in regulating NK cell activity, KLRC1 is a potential target for therapeutic interventions aimed at modulating the immune response. Strategies to inhibit KLRC1/CD94 interactions could enhance the cytotoxic activity of NK cells against tumor cells and virally infected cells. Conversely, enhancing KLRC1 activity could be beneficial in preventing autoimmune diseases and reducing tissue damage during inflammatory responses .
