KLHDC8B Human

Kelch Domain Containing 8B Human Recombinant

Cat. No.

BT19081

Source

Escherichia Coli.

Synonyms

Kelch Domain Containing 8B, Kelch Domain-Containing Protein 8B, CHL, KLHDC8B.

Appearance

Sterile Filtered clear solution.

Purity

Greater than 85.0% as determined by SDS-PAGE.

Usage

Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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Description

KLHDC8B Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 377 amino acids (1-354 a.a) and having a molecular mass of 40.1kDa.

KLHDC8B is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Product Specs

Introduction

Kelch Domain Containing 8B, also known as KLHDC8B, forms a distinct beta-propeller protein structure of kelch domains, which facilitate protein-protein interactions. Additionally, mutations in KLHDC8B have been linked to Hodgkin lymphoma.

Description

Recombinant human KLHDC8B protein, produced in E. coli, is a single, non-glycosylated polypeptide chain consisting of 377 amino acids (residues 1-354) and possessing a molecular weight of 40.1 kDa. The KLHDC8B protein is fused to a 23 amino acid His-tag at the N-terminus and purified using proprietary chromatographic techniques.

Physical Appearance

Sterile filtered, clear solution.

Formulation

The KLHDC8B protein solution has a concentration of 0.5 mg/mL and is supplied in phosphate-buffered saline (pH 7.4) with 10% glycerol.

Stability

For short-term storage (2-4 weeks), keep at 4°C. For extended storage, freeze at -20°C. The addition of a carrier protein (0.1% HSA or BSA) is recommended for long-term storage. Avoid repeated freeze-thaw cycles.

Purity

Purity exceeds 85.0% as determined by SDS-PAGE analysis.

Synonyms

Kelch Domain Containing 8B, Kelch Domain-Containing Protein 8B, CHL, KLHDC8B.

Source

Escherichia Coli.

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGSMSAGGGR AFAWQVFPPM PTCRVYGTVA HQDGHLLVLG GCGRAGLPLD TAETLDMASH TWLALAPLPT ARAGAAAVVL GKQVLVVGGV DEVQSPVAAV EAFLMDEGRW ERRATLPQAA MGVATVERDG MVYALGGMGP DTAPQAQVRV YEPRRDCWLS LPSMPTPCYG ASTFLHGNKI YVLGGRQGKL PVTAFEAFDL EARTWTRHPS LPSRRAFAGC AMAEGSVFSL GGLQQPGPHN FYSRPHFVNT VEMFDLEHGS WTKLPRSLRM RDKRADFVVG SLGGHIVAIG GLGNQPCPLG SVESFSLARR RWEALPAMPT ARCSCSSLQA GPRLFVIGGV AQGPSQAVEA LCLRDGV.

Product Science Overview

Structure and Function

KLHDC8B is characterized by its beta-propeller structure formed by multiple Kelch repeats. This structure allows the protein to interact with other proteins, facilitating various cellular processes. One of the key functions of KLHDC8B is its involvement in cytokinesis, the process where a single cell divides into two daughter cells. It plays a critical role in ensuring the proper segregation of chromosomes and nuclei during cell division, thereby maintaining chromosomal stability and preventing mitotic errors.

Genetic Implications

Mutations in the KLHDC8B gene have been associated with Hodgkin lymphoma, a type of cancer that originates from white blood cells called lymphocytes. These mutations can disrupt the normal function of the protein, leading to uncontrolled cell division and tumor formation .

Research and Applications

Research on KLHDC8B has provided valuable insights into its role in cell division and its implications in cancer. Understanding the molecular mechanisms of KLHDC8B can aid in the development of targeted therapies for diseases associated with its dysfunction. Additionally, recombinant forms of KLHDC8B are used in various research applications to study its structure and function in detail.

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KLHDC8B Human

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Product Specs

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