JTB Human

Jumping translocations are rare chromosomal rearrangements characterized by the re-localization of one donor chromosome to multiple recipient chromosomes . These translocations result in the amplification of specific chromosomal segments that jump to various telomeres . JTs have been reported in neoplasms and constitutional chromosome abnormalities, but they are particularly rare in neoplastic diseases .

JTB is expressed in all normal human tissues but is overexpressed or underexpressed in many malignant counterparts . It plays a crucial role in the regulation of cell proliferation and is required for normal cytokinesis during mitosis . JTB may also be a component of the chromosomal passenger complex (CPC), which is essential for correct chromosome alignment and segregation during cell division .

Jumping translocations involve the fusion of the break-off donor chromosome segment to telomeric or interstitial regions of recipient chromosomes, forming different chromosomal patterns . For example, jumping translocations involving the 1q12–21 segment are nonrandomly involved in multiple myeloma and malignant lymphoproliferative disorders . These translocations are associated with a high risk of transformation to acute myeloid leukemia, resistance to chemotherapy, and poor survival rates .

Recombinant human JTB protein is often used in research to study its role in cell proliferation and cancer. The protein is typically expressed in HEK293 cells and purified for various experimental applications . Understanding the function and mechanism of JTB can provide insights into the development of targeted therapies for cancers involving jumping translocations.