ITGB1BP3 Human

Integrin Beta 1 Binding Protein 3 (IB1BP3) is a recombinant protein derived from human sources. Integrins are a family of cell surface receptors that mediate cell-cell and cell-extracellular matrix (ECM) interactions. They play crucial roles in various biological processes, including cell adhesion, migration, proliferation, and differentiation.

Integrins are heterodimeric proteins composed of alpha (α) and beta (β) subunits. The β1 subunit is one of the most common and versatile integrin subunits, forming heterodimers with multiple α subunits. Integrin Beta 1 Binding Protein 3 specifically interacts with the β1 subunit, influencing its function and regulation.

Integrin β1 is ubiquitously expressed in various tissues, including endothelial cells, fibroblasts, and tumor cells. Its widespread distribution underscores its importance in maintaining tissue integrity and facilitating cellular communication.

Integrin β1 plays a pivotal role in several cellular processes:

• Cell Adhesion: Integrin β1 mediates the attachment of cells to the ECM, providing structural support and facilitating tissue organization.
• Migration and Invasion: It is involved in cell migration and invasion, processes critical for wound healing, immune responses, and cancer metastasis.
• Signal Transduction: Integrin β1 participates in signal transduction pathways that regulate cell survival, proliferation, and differentiation. Key signaling pathways include FAK, AKT, MAPK, and Src family kinases .

Integrin β1 functions through its interaction with ECM components such as collagen, fibronectin, and laminin. Upon ligand binding, integrin β1 undergoes conformational changes that activate intracellular signaling cascades. These signals modulate cytoskeletal dynamics, gene expression, and cellular responses to environmental cues.

The activity of integrin β1 is tightly regulated by various mechanisms:

• Post-translational Modifications: Phosphorylation, glycosylation, and ubiquitination of integrin β1 influence its stability, localization, and function.
• Interaction with Cytoplasmic Proteins: Proteins such as talin and kindlin bind to the cytoplasmic tail of integrin β1, modulating its activation and signaling .
• Extracellular Ligands: The binding of ECM proteins to integrin β1 triggers outside-in signaling, while intracellular signals can induce inside-out activation of integrin β1.

Given its central role in cell adhesion and signaling, integrin β1 is implicated in various pathological conditions, including cancer, fibrosis, and inflammatory diseases. Targeting integrin β1 and its binding proteins holds therapeutic potential for modulating these conditions.