IL11RA Rat

Interleukin 11 Receptor Subunit Alpha (IL11RA) is a protein that belongs to the hematopoietic cytokine receptor family. It serves as a receptor for interleukin-11 (IL-11), a stromal cell-derived cytokine. IL-11 is part of a family of pleiotropic and redundant cytokines that utilize the gp130 transducing subunit in their high-affinity receptors . The IL11RA protein is involved in various biological processes, including the control of proliferation and differentiation of skeletogenic progenitor or other mesenchymal cells .

IL11RA is a single, glycosylated polypeptide chain containing 356 amino acids, with a molecular mass of approximately 39.2 kDa . The receptor systems for IL-6, LIF, OSM, CNTF, IL-11, and CT-1 can utilize IL6ST for initiating signal transmission . The IL11RA protein is expressed in various tissues, including lymphoid tissue, bone marrow, testis, and skeletal muscle .

IL11RA plays a crucial role in the immune system and cell proliferation. It is involved in the control of proliferation and differentiation of skeletogenic progenitor or other mesenchymal cells . The IL11/IL11RA/IL6ST complex is essential for initiating signal transmission and regulating various biological processes .

The recombinant IL11RA protein is produced in Sf9 Baculovirus cells. It is a single, glycosylated polypeptide chain containing 356 amino acids and is fused with an 8 amino acids His tag at the C-terminus. The protein is purified using proprietary chromatographic techniques . The IL11RA protein solution is formulated with phosphate-buffered saline (pH 7.4) and 10% glycerol .

The IL11RA protein should be stored at 4°C if used within 2-4 weeks. For longer storage periods, it should be frozen at -20°C. It is recommended to add a carrier protein (0.1% HSA or BSA) for long-term storage. Avoid multiple freeze-thaw cycles to maintain protein stability .