IGSF8 Human
Sf9, Baculovirus cells.
Immunoglobulin Superfamily Member 8, Keratinocytes-Associated Transmembrane Protein 4, Glu-Trp-Ile EWI Motif-Containing Protein 2, Prostaglandin Regulatory-Like Protein, CD81 Partner 3, CD81P3, LIR-D1, EWI-2, KCT-4, EWI2, PGRL, Immunoglobulin Superfamily Member 8, CD316 Antigen, CD316, IgSF8, KCT4.
Greater than 95.0% as determined by SDS-PAGE.
Description
IGSF8 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 561 amino acids (28-579a.a.) and having a molecular mass of 59.6kDa (Molecular size on SDS-PAGE will appear at approximately 50-70kDa). IGSF8 is expressed with a 6 amino acids His tag at C-Terminus and purified by proprietary chromatographic techniques.
Product Specs
Immunoglobulin Superfamily Member 8, Keratinocytes-Associated Transmembrane Protein 4, Glu-Trp-Ile EWI Motif-Containing Protein 2, Prostaglandin Regulatory-Like Protein, CD81 Partner 3, CD81P3, LIR-D1, EWI-2, KCT-4, EWI2, PGRL, Immunoglobulin Superfamily Member 8, CD316 Antigen, CD316, IgSF8, KCT4.
Sf9, Baculovirus cells.
ADLREVLVPE GPLYRVAGTA VSISCNVTGY EGPAQQNFEW FLYRPEAPDT ALGIVSTKDT QFSYAVFKSR VVAGEVQVQR LQGDAVVLKI ARLQAQDAGI YECHTPSTDT RYLGSYSGKV ELRVLPDVLQ VSAAPPGPRG RQAPTSPPRM TVHEGQELAL GCLARTSTQK HTHLAVSFGR SVPEAPVGRS TLQEVVGIRS DLAVEAGAPY AERLAAGELR LGKEGTDRYR MVVGGAQAGD AGTYHCTAAE WIQDPDGSWA QIAEKRAVLA HVDVQTLSSQ LAVTVGPGER RIGPGEPLEL LCNVSGALPP AGRHAAYSVG WEMAPAGAPG PGRLVAQLDT EGVGSLGPGY EGRHIAMEKV ASRTYRLRLE AARPGDAGTY RCLAKAYVRG SGTRLREAAS ARSRPLPVHV REEGVVLEAV AWLAGGTVYR GETASLLCNI SVRGGPPGLR LAASWWVERP EDGELSSVPA QLVGGVGQDG VAELGVRPGG GPVSVELVGP RSHRLRLHSL GPEDEGVYHC APSAWVQHAD YSWYQAGSAR SGPVTVYPYM HALDTHHHHH H.
Product Science Overview
Immunoglobulin Superfamily Member 8 (IGSF8), also known as EWI-2, PGRL, and CD316, is a cell surface protein that belongs to the immunoglobulin superfamily (IgSF). This superfamily is characterized by the presence of immunoglobulin domains, which are involved in various cellular processes such as recognition, binding, and adhesion .
IGSF8 contains four extracellular immunoglobulin domains, one transmembrane domain, and a short cytoplasmic tail . The immunoglobulin domains are responsible for the protein’s ability to interact with other molecules, such as tetraspanins CD9 and CD81 . These interactions play a crucial role in modulating cell adhesion, migration, and growth .
IGSF8 is involved in several cellular processes, including:
- Cell Adhesion: IGSF8 modulates cell adhesion by interacting with tetraspanins, which are proteins that organize the cell membrane and facilitate cell-cell interactions .
- Cell Migration: The protein plays a role in cell migration, which is essential for various physiological processes such as wound healing and immune responses .
- Cell Growth: IGSF8 influences cell growth by regulating signaling pathways that control cell proliferation and differentiation .
IGSF8 has been implicated in various diseases, particularly in cancer. Studies have shown that IGSF8 is associated with prognosis and metastasis in several solid tumors . Additionally, IGSF8 is indispensable for the propagation of myeloid leukemia and the maintenance of leukemia stem cells . Deletion of IGSF8 in leukemia models has been shown to reduce the number of leukemic colonies and increase survival rates .
Research on IGSF8 continues to uncover its roles in normal physiology and disease. The protein’s interactions with tetraspanins and its involvement in critical cellular processes make it a potential target for therapeutic interventions. For instance, targeting IGSF8 in cancer treatment could inhibit tumor growth and metastasis .
