IGLL1 Human
Immunoglobulin Lambda-Like Polypeptide 1 Human Recombinant
Cat. No.
BT23221
Source
E.coli.
Synonyms
14.1, AGM2, CD179b, IGL1, IGL5, IGLJ14.1, IGLL, IGO, IGVPB, VPREB2, Immunoglobulin lambda-like polypeptide 1, CD179 antigen-like family member B, Ig lambda-5, Immunoglobulin omega polypeptide, Immunoglobulin-related protein 14.1, IGLL1.
Appearance
Sterile Filtered colorless solution.
Purity
Greater than 85% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Shipped with Ice Packs 
In Stock 
Description
IGLL1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 199 amino acids (38-213a.a.) and having a molecular mass of 21.5kDa. IGLL1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Introduction
Immunoglobulin Lambda-Like Polypeptide 1 (IGLL1), a member of the immunoglobulin gene superfamily, serves as a substitute light chain subunit and doesn't undergo rearrangement. This polypeptide is involved in the formation of immunoglobulins, with two known transcript variants producing different isoforms. Mutations in the IGLL1 gene can lead to B cell deficiency and agammaglobulinemia, an autosomal recessive disorder characterized by significantly reduced or absent gamma globulin (antibody) production.
Description
Recombinant Human IGLL1, produced in E. coli, is a single, non-glycosylated polypeptide chain comprising 199 amino acids (38-213a.a.). This protein, with a molecular weight of 21.5 kDa, features a 23 amino acid His-tag at the N-terminus and is purified using proprietary chromatographic techniques.
Physical Appearance
Clear, colorless, and sterile-filtered solution.
Formulation
The IGLL1 protein solution is provided at a concentration of 1mg/ml in a buffer consisting of 20mM Tris-HCl (pH 8.0), 0.4M urea, and 10% glycerol.
Stability
For short-term storage (2-4 weeks), the product can be stored at 4°C. For extended storage, it is recommended to freeze the product at -20°C. The addition of a carrier protein (0.1% HSA or BSA) is advised for long-term storage. Avoid repeated freezing and thawing cycles.
Purity
The purity is determined to be greater than 85% via SDS-PAGE analysis.
Synonyms
14.1, AGM2, CD179b, IGL1, IGL5, IGLJ14.1, IGLL, IGO, IGVPB, VPREB2, Immunoglobulin lambda-like polypeptide 1, CD179 antigen-like family member B, Ig lambda-5, Immunoglobulin omega polypeptide, Immunoglobulin-related protein 14.1, IGLL1.
Source
E.coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSLLRPTAA SQSRALGPGA PGGSSRSSLR SRWGRFLLQR GSWTGPRCWP RGFQSKHNSV THVFGSGTQL TVLSQPKATP SVTLFPPSSE ELQANKATLV CLMNDFYPGI LTVTWKADGT PITQGVEMTT PSKQSNNKYA ASSYLSLTPE QWRSRRSYSC QVMHEGSTVE KTVAPAECS.
Product Science Overview
Structure and Function
IGLL1 is a part of the surrogate light chain of the pre-B cell receptor complex. The pre-B cell receptor is found on the surface of pro-B and pre-B cells, where it is involved in several critical processes:
- Signal Transduction: It helps in the transduction of signals necessary for cellular proliferation and differentiation from the pro-B cell to the pre-B cell stage .
- Allelic Exclusion: It ensures allelic exclusion at the immunoglobulin heavy chain gene locus, which is vital for the proper functioning of B-cells .
- Gene Rearrangement: It promotes the rearrangement of immunoglobulin light chain genes .
Genetic and Clinical Significance
The IGLL1 gene does not undergo rearrangement, which is a unique feature compared to other immunoglobulin genes . Mutations in this gene can lead to significant clinical conditions, such as:
- B Cell Deficiency: A lack of functional B-cells can result in a compromised immune system .
- Agammaglobulinemia: This is an autosomal recessive disease characterized by the absence or severe reduction of gamma globulins or antibodies in the blood . Patients with this condition are highly susceptible to infections.
Expression and Localization
Research and Applications
Recombinant forms of IGLL1 are used in research to study its role in B-cell development and related immune functions. Understanding the mechanisms involving IGLL1 can provide insights into immune deficiencies and potential therapeutic targets for related diseases.
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