IgG1 Fc Human
HEK293 Cells
IGHG1, IGHG-1, IGG-1FC, IGG1FC, IGG1-FC
Greater than 90% as determined by SDS-PAGE.
Description
IgG1 Fc Human Recombinant produced in HEK is a single polypeptide chain containing 231 amino acids (100-330) and having a molecular mass of 25.9kDa. IgG1 Fc is purified by proprietary chromatographic techniques.
Product Specs
IGHG1, IGHG-1, IGG-1FC, IGG1FC, IGG1-FC
HEK293 Cells
PKSCDKTHTC PPCPAPELLG GPSVFLFPPK PKDTLMISRT PEVTCVVVDV SHEDPEVKFN WYVDGVEVHN AKTKPREEQY NSTYRVVSVL TVLHQDWLNG KEYKCKVSNK ALPAPIEKTI SKAKGQPREP QVYTLPPSRD ELTKNQVSLT CLVKGFYPSD IAVEWESNGQ PENNYKTTPP VLDSDGSFFL YSKLTVDKSR WQQGNVFSCS VMHEALHNHY TQKSLSLSPG K
Product Science Overview
Immunoglobulin Heavy Constant Gamma 1 (IGHG1) is a protein encoded by the IGHG1 gene in humans. This protein is a crucial component of the immune system, specifically involved in the humoral immune response. Immunoglobulins, also known as antibodies, are glycoproteins produced by B lymphocytes. They play a vital role in identifying and neutralizing pathogens such as bacteria and viruses.
The IGHG1 protein is part of the constant region of the heavy chain of Immunoglobulin G (IgG), one of the five major classes of antibodies. The heavy chain constant region is responsible for defining the antibody’s class and mediating its effector functions. The IGHG1 protein consists of 330 amino acids and is expressed in various tissues, including the extracellular space .
The primary function of IGHG1 is to mediate the effector phase of the humoral immune response. This involves the elimination of bound antigens through various mechanisms such as antibody-dependent cellular cytotoxicity (ADCC) and complement activation . The antigen-binding site of an antibody is formed by the variable domain of one heavy chain and its associated light chain, allowing each immunoglobulin to have two antigen-binding sites with high affinity for specific antigens .
Recombinant IGHG1 refers to the artificially produced version of the IGHG1 protein using recombinant DNA technology. This technology involves inserting the gene encoding IGHG1 into a suitable expression system, such as HEK 293 cells, to produce the protein in large quantities. Recombinant IGHG1 is used in various research and therapeutic applications, including the development of monoclonal antibodies and the study of immune responses .
IGHG1 is associated with several diseases, including chronic lymphocytic leukemia and follicular lymphoma . The protein’s role in immune responses makes it a target for therapeutic interventions in autoimmune diseases, infections, and cancer. Monoclonal antibodies targeting specific antigens can be engineered using recombinant IGHG1, providing a powerful tool for treating various conditions.
The IGHG1 gene has undergone significant evolution and genetic variability, contributing to the diversity of the immune response. This variability allows the immune system to recognize and respond to a wide range of pathogens. The gene is located on chromosome 14 and has several paralogs, including IGHG3, which share similar functions .
