IGFLR1 Human

IGF-Like Family Receptor 1 Human Recombinant
Cat. No.
BT16059
Source
E.coli.
Synonyms
TMEM149, U2AF1L4, IGF-like family receptor 1, Transmembrane protein 149, U2 small nuclear RNA auxiliary factor 1-like 4, IGFLR1. 
Appearance
Sterile Filtered colorless solution.
Purity
Greater than 90% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description

IGFLR1 Human Recombinant produced in E. coli is a single polypeptide chain containing 164 amino acids (23-163) and having a molecular mass of 17.5kDa. IGFLR1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Product Specs

Introduction
IGF-like family receptor 1 (IGFLR1), encoded by a gene located on human chromosome 19, is a cell membrane receptor known for its interaction with IGF-like family proteins. It exhibits a strong binding affinity for IGFL1 and IGFL3, and potentially interacts with IGFL2.
Description
Recombinant human IGFLR1, produced in E. coli, is a single polypeptide chain comprising 164 amino acids (residues 23-163) with a molecular weight of 17.5 kDa. This protein includes a 23 amino acid His-tag fused at the N-terminus and is purified using proprietary chromatographic methods.
Physical Appearance
A clear, sterile-filtered solution.
Formulation
The IGFLR1 solution is provided at a concentration of 0.25 mg/ml in a buffer consisting of 20 mM Tris-HCl (pH 7.5), 0.2 M NaCl, 50% glycerol, and 2 mM DTT.
Stability
For short-term storage (2-4 weeks), the solution can be stored at 4°C. For extended storage, it is recommended to freeze the solution at -20°C. Adding a carrier protein (0.1% HSA or BSA) is advisable for long-term storage. Repeated freezing and thawing should be avoided.
Purity
The purity is determined to be greater than 90% based on SDS-PAGE analysis.
Synonyms
TMEM149, U2AF1L4, IGF-like family receptor 1, Transmembrane protein 149, U2 small nuclear RNA auxiliary factor 1-like 4, IGFLR1. 
Source
E.coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSSQYCGRL EYWNPDNKCC SSCLQRFGPP PCPDYEFREN CGLNDHGDFV TPPFRKCSSG QCNPDGAELC SPCGGGAVTP TPAAGGGRTP WRCRERPVPA KGHCPLTPGN PGAPSSQERS SPASSIAWRT PEPVPQQAWP NFLP.

Product Science Overview

Introduction

IGF-Like Family Receptor 1 (IGFLR1) is a protein encoded by the IGFLR1 gene in humans. This receptor is part of the insulin-like growth factor (IGF) family, which plays a crucial role in various biological processes, including growth, development, and metabolism .

Classification

IGFLR1 is classified as a protein-coding gene and is also known by several aliases, including TMEM149 and U2AF1L4 . It belongs to the IGF-like (IGFL) family, which includes four genes (IGFL1, IGFL2, IGFL3, IGFL4) and two pseudogenes (IGFL1P1 and IGFL1P2) . The IGFL family is characterized by small secreted proteins containing conserved cysteine residues .

Biological Properties

IGFLR1 is a probable cell membrane receptor for IGF-like family proteins. It binds IGFL1 and IGFL3 with higher affinity and may also bind IGFL2 . The receptor is localized to the plasma membrane and nucleoplasm . It is expressed in various tissues, including the lymph nodes, spleen, and kidneys .

Functions

The primary function of IGFLR1 is to act as a receptor for IGF-like family proteins. It plays a significant role in cell growth, proliferation, and survival . The receptor is upregulated by pro-inflammatory cytokines such as TNF-α and is involved in tissue inflammation . IGFLR1 is also implicated in various diseases, including spinocerebellar ataxia .

Modes of Action

IGFLR1 mediates its effects through binding to IGF-like proteins, which triggers a cascade of intracellular signaling pathways. These pathways promote cell division, growth, and differentiation . The receptor’s activation is crucial for maintaining cellular homeostasis and responding to external stimuli .

Regulatory Mechanisms

The expression and activity of IGFLR1 are regulated by various factors, including cytokines and growth factors . The receptor’s regulation is essential for its role in inflammation and immune responses . Additionally, IGFLR1 is involved in the regulation of other growth factor pathways, such as TGF-β and EGF .

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