IFNGR1 Human

IFNGR1 is the ligand-binding chain (alpha) of the gamma interferon receptor. The human interferon-gamma receptor is a heterodimer composed of IFNGR1 and IFNGR2 . When interferon-gamma (IFN-γ) binds to IFNGR1, it induces the rapid dimerization of the receptor chains, which is crucial for signal transduction and subsequent immune responses .

Recombinant human IFNGR1 is produced using advanced biotechnological methods. Typically, the gene encoding IFNGR1 is inserted into a suitable expression system, such as E. coli or a mammalian cell line. The recombinant protein is then purified using techniques like column chromatography to ensure high purity and activity .

Recombinant IFNGR1 is widely used in research to study the IFN-γ signaling pathway and its role in immune responses. It is also used in the development of therapeutic agents targeting diseases where IFN-γ plays a critical role, such as chronic infections and certain autoimmune disorders .

Genetic variations in IFNGR1 have been associated with susceptibility to infections, such as Helicobacter pylori . Understanding the function and regulation of IFNGR1 is vital for developing new therapeutic strategies for infectious and inflammatory diseases.

Recombinant IFNGR1 is typically lyophilized and stored at -20 to -70°C to maintain its stability and activity. It is reconstituted in sterile, deionized water or PBS before use in experiments .