IFNAR2 Human

Interferon Alpha And Beta Receptor Subunit 2 Human Recombinant
Cat. No.
BT27559
Source

Sf9, Baculovirus cells.

Synonyms

Interferon alpha/beta receptor 2, IFNAR2, IFN-alpha binding protein, Interferon alpha binding protein, Type I interferon receptor 2, interferon alpha/beta receptor 2 isoform a, IFN-R-2, IFNABR, IFNARB, IFN-alpha-REC, IFN-R, IMD45.

Appearance
Sterile Filtered colorless solution.
Purity

Greater than 90.0% as determined by SDS-PAGE.

Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description

IFNAR2 Human Recombinant produced in Baculovirus is a single glycosylated polypeptide chain containing 456 amino acids (27-243 a.a.) and having a molecular mass of  51.7kDa. IFNAR2 is fused to an 239 amino acid  hIgG-His tag at C-terminus and purified by proprietary chromatographic techniques.

Product Specs

Introduction
Interferon Alpha and Beta Receptor Subunit 2, also known as IFNAR2, belongs to the class II cytokine receptor family. It plays a critical role in the innate immune response by mediating the effects of type I interferons (IFNs). Upon activation of innate immune signaling pathways, rapid induction of type I IFNs occurs due to their intronless gene structure. IFNAR2 serves as the primary ligand-binding receptor for type I IFNs. Ligand binding to IFNAR2 leads to receptor stabilization and the formation of a signaling complex. This complex subsequently activates downstream signaling pathways, including the JAK-STAT pathway, resulting in the expression of IFN-stimulated genes involved in antiviral, antiproliferative, and immunomodulatory responses.
Description
Recombinant IFNAR2, human, produced in Baculovirus is a single, glycosylated polypeptide chain. This protein consists of 456 amino acids, spanning from residue 27 to 243, with a molecular weight of 51.7 kDa. A 239 amino acid hIgG-His tag is fused to the C-terminus of IFNAR2. The protein undergoes purification using proprietary chromatographic methods.
Physical Appearance
A clear, colorless solution that has been sterilized by filtration.
Formulation
IFNAR2 protein is supplied at a concentration of 0.25 mg/ml in a solution containing 10% glycerol and Phosphate-Buffered Saline (pH 7.4).
Stability
For short-term storage (2-4 weeks), the product can be stored at 4°C. For long-term storage, it is recommended to store the product at -20°C. To further enhance stability during long-term storage, the addition of a carrier protein (0.1% HSA or BSA) is advised. Avoid repeated freeze-thaw cycles to maintain protein integrity and activity.
Purity
The purity of this product is greater than 90.0% as determined by SDS-PAGE analysis.
Synonyms

Interferon alpha/beta receptor 2, IFNAR2, IFN-alpha binding protein, Interferon alpha binding protein, Type I interferon receptor 2, interferon alpha/beta receptor 2 isoform a, IFN-R-2, IFNABR, IFNARB, IFN-alpha-REC, IFN-R, IMD45.

Source

Sf9, Baculovirus cells.

Amino Acid Sequence

ISYDSPDYTD ESCTFKISLR NFRSILSWEL KNHSIVPTHY TLLYTIMSKP EDLKVVKNCA NTTRSFCDLT DEWRSTHEAY VTVLEGFSGN TTLFSCSHNF WLAIDMSFEP PEFEIVGFTN HINVMVKFPS IVEEELQFDL SLVIEEQSEG IVKKHKPEIK GNMSGNFTYI IDKLIPNTNY CVSVYLEHSD EQAVIKSPLK CTLLPPGQES ESAESAKLEP KSCDKTHTCP PCPAPELLGG PSVFLFPPKP KDTLMISRTP EVTCVVVDVS HEDPEVKFNW YVDGVEVHNA KTKPREEQYN STYRVVSVLT VLHQDWLNGK EYKCKVSNKA LPAPIEKTIS KAKGQPREPQ VYTLPPSRDE LTKNQVSLTC LVKGFYPSDI AVEWESNGQP ENNYKTTPPV LDSDGSFFLY SKLTVDKSRW QQGNVFSCSV MHEALHNHYT QKSLSLSPGK HHHHHH.

Product Science Overview

Structure and Function

IFNAR2 is a glycoprotein that belongs to the class II cytokine receptor family . It forms a heterodimeric receptor complex with IFNAR1, another subunit of the type I interferon receptor . This receptor complex binds to type I interferons, which include interferons-α, -β, -ε, -κ, -ω, and -ζ . Upon binding to these interferons, IFNAR2 activates several signaling pathways, including the JAK-STAT pathway, MAPK, PI3K, and Akt signaling pathways .

Biological Activity

The activation of IFNAR2 leads to the transcription of over 2000 different genes, resulting in a wide range of biological effects . These effects include antiviral responses, modulation of cell differentiation, proliferation, apoptosis, and autophagy . The diverse effects of type I interferons are dependent on the cellular and environmental context .

Recombinant Human IFNAR2

Recombinant human IFNAR2 is produced using recombinant DNA technology, which involves inserting the gene encoding IFNAR2 into a suitable expression system, such as Chinese Hamster Ovary (CHO) cells . This allows for the large-scale production of IFNAR2 for research and therapeutic purposes. Recombinant IFNAR2 is used in various studies to understand its role in immune responses and to develop potential therapeutic applications .

Clinical Applications

The type I interferons, including those that bind to IFNAR2, have been extensively studied for their antiviral, antitumor, and immunomodulatory properties . Recombinant human IFNAR2 is used in research to explore these properties and to develop new treatments for viral infections, cancers, and autoimmune diseases .

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