HERV-K
Escherichia Coli.
Sterile Filtered clear solution.
Protein is >90% pure as determined by SDS PAGE.
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY.They may not be used as drugs,agricultural or pesticidal products, food additives or household chemicals.
Description
The E.Coli derived HERV-K recombinant truncated protein is fused to a Six histidine tag at C-terminus and has a MW of 51.5kDa (pI 9.06).
Product Specs
Escherichia Coli.
MWTVPSFTND SYQVYNVFST NSFQLLTVKR TPHEAWRVPL TTKTNKTKGL PDCPKKPTNG PFIVTSILWD NCNAPKAVVL QTLAMGIVID WAPKGHYWQD CSSKNTLCSE FIYSLDYIEH GWQSYTMRQR VSPYPFKWMD TGIAPPRPKI IHPFFTPEHP ELWKLAAALS GIKIWNTTYQ LLRTKTKTPT FNITLISEWV IPIRSCVKPP YMLLVGNIIM MPDAQTIECH NCKLFTCIDA TFNPTTSILL VRAREGVWIP VSLHRPWESS PSIHIVNEVL KDILKRTKRF IFTLIAVLAG LLAVTATAAT AGVAIRSSVQ TAHYVEACQK NSSRLWNSQA QIDQKLANQI NDLRQSVTWL GDRVMNLQHR MQLQCDWNTS DYCITPYAYN QDQHSWENVS RHLKAWDDNL TLDISQLKEQIFEASQAHLS TVPGSHIFEG ITKQLPDFNP FKWLKPVRGS LLLLALLILV CLCCLLLVCRCL.
Product Science Overview
Human endogenous retroviruses (HERVs) are remnants of ancient viral infections that have integrated into the human genome. These viral sequences are passed down through generations and now constitute approximately 8% of the human genome . HERVs are classified based on the tRNA primer binding site used to initiate reverse transcription, and they are generally defective in viral replication due to accumulated mutations and deletions .
Among the various HERV families, HERV-K (HML-2) is one of the most recently integrated and biologically active groups. HERV-K retains open reading frames (ORFs) capable of encoding functional proteins, including the Gag, Pol, and Env proteins . The envelope (Env) protein of HERV-K is particularly noteworthy as it plays a crucial role in viral entry and has been implicated in various physiological and pathological processes .
The Env protein of HERV-K is a glycoprotein that facilitates the virus’s entry into host cells by mediating the fusion of the viral and cellular membranes. This protein is composed of two subunits: the surface (SU) subunit, which is responsible for receptor binding, and the transmembrane ™ subunit, which mediates membrane fusion . The Env protein is also known for its immunosuppressive properties, which can modulate the host immune response .
The recombinant HERV-K Env protein is produced using recombinant DNA technology, where the gene encoding the Env protein is cloned and expressed in a suitable host system, such as bacteria or mammalian cells. This recombinant protein can be used for various research purposes, including studying the protein’s structure and function, developing diagnostic tools, and exploring its potential as a therapeutic target .
HERV-K Env protein has been associated with several diseases, including cancer and autoimmune disorders. Reactivation of HERV-K expression has been observed in various cancers, such as melanoma, breast cancer, and ovarian cancer . The Env protein’s immunosuppressive properties may contribute to tumor immune evasion, making it a potential target for cancer immunotherapy .
In addition to its role in cancer, HERV-K Env protein has been implicated in neurological disorders, such as amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS). The protein’s expression in the central nervous system and its potential to induce neuroinflammation highlight its relevance in these diseases .
