HSPBAP1 Human
HSPB Associated Protein 1 Human Recombinant
Cat. No.
BT18953
Source
Escherichia Coli.
Synonyms
HSPB (heat shock 27kDa) associated protein 1, Protein associated with small stress protein 1, PASS1, FLJ22623, FLJ39386.
Appearance
Sterile Filtered colorless solution.
Purity
Greater than 80.0% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description
HSPBAP1 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 508 amino acids (1-488a.a.) and having a molecular mass of 57.3kDa.
The HSPBAP1 is purified by proprietary chromatographic techniques.
The HSPBAP1 is purified by proprietary chromatographic techniques.
Product Specs
Introduction
HSPBAP1 is a protein that contains a jumonji C (JMJC) domain. It plays a role in regulating the cellular stress response and is known to interact with CRYAB and HSPB1.
Description
Recombinant human HSPBAP1 protein has been engineered with a 20 amino acid His tag at its N-terminus. It is produced in E. coli as a single, non-glycosylated polypeptide chain consisting of 508 amino acids (residues 1-488) and has a molecular weight of 57.3 kDa. The protein undergoes purification using proprietary chromatographic techniques.
Physical Appearance
A clear and colorless solution that has been sterilized through filtration.
Formulation
The HSPBAP1 solution is provided at a concentration of 0.25 mg/mL in phosphate-buffered saline (pH 7.4).
Stability
It is recommended to store HSPBAP1 at a temperature below -18°C. For long-term storage, it is advisable to add a carrier protein such as 0.1% HSA or BSA. Avoid repeated freeze-thaw cycles to maintain protein integrity.
Purity
The purity of HSPBAP1 is determined to be greater than 80.0% using SDS-PAGE analysis.
Synonyms
HSPB (heat shock 27kDa) associated protein 1, Protein associated with small stress protein 1, PASS1, FLJ22623, FLJ39386.
Source
Escherichia Coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MAAGSEATTP VIVAAGAGGE EGEHVKPFKP EKAKEIIMSL QQPAIFCNMV FDWPARHWNA KYLSQVLHGK QIRFRMGMKS MSTVPQFETT CNYVEATLEE FLTWNCDQSS ISGPFRDYDH SKFWAYADYK YFVSLFEDKT DLFQDVKWSD FGFPGRNGQE
STLWIGSLGA HTPCHLDSYG CNLVFQVQGR KRWHLFPPED TPFLYPTRIP YEESSVFSKI NVVNPDLKRF PQFRKAQRHA VTLSPGQVLF VPRHWWHYVE SIDPVTVSIN SWIELEEDHL ARVEEAITRM LVCALKTAEN PQNTRAWLNP TEVEETSHAV NCCYLNAAVS AFFDRCRTSE VVEIQALRTD GEHMKKEELN VCNHMEVGQT GSQNLTTGTD KPEAASPFGP DLVPVAQRSE EPPSERGGIF GSDGKDFVDK DGEHFGKLHC AKRQQIMSNS ENAIEEQIAS NTTTTPQTFI STDDLLDCLV NPQVTRIVAQ LLIQGRSL
STLWIGSLGA HTPCHLDSYG CNLVFQVQGR KRWHLFPPED TPFLYPTRIP YEESSVFSKI NVVNPDLKRF PQFRKAQRHA VTLSPGQVLF VPRHWWHYVE SIDPVTVSIN SWIELEEDHL ARVEEAITRM LVCALKTAEN PQNTRAWLNP TEVEETSHAV NCCYLNAAVS AFFDRCRTSE VVEIQALRTD GEHMKKEELN VCNHMEVGQT GSQNLTTGTD KPEAASPFGP DLVPVAQRSE EPPSERGGIF GSDGKDFVDK DGEHFGKLHC AKRQQIMSNS ENAIEEQIAS NTTTTPQTFI STDDLLDCLV NPQVTRIVAQ LLIQGRSL
Product Science Overview
Gene and Protein Information
Function and Role
HSPBAP1 is involved in various cellular processes, including:
- Protein Folding: It acts as a molecular chaperone, assisting in the proper folding of other proteins, especially under stress conditions .
- Stress Response: It plays a crucial role in the cellular response to environmental stress by translocating from the cytoplasm to the nucleus .
- Cancer: Expression of HSPB1, which interacts with HSPBAP1, is correlated with poor clinical outcomes in multiple human cancers. It may promote cancer cell proliferation and metastasis while protecting cancer cells from apoptosis .
Expression and Localization
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