HSPA13 Antibody
Heat shock protein 70kDa family member 13, STCH, Stress 70 protein chaperone microsome-associated 60kD, Microsomal stress-70 protein ATPase core.
Description
Product Specs
Heat shock protein 70kDa family member 13, STCH, Stress 70 protein chaperone microsome-associated 60kD, Microsomal stress-70 protein ATPase core.
HSPA13 antibody was purified from mouse ascitic fluids by protein-A affinity chromatography.
PAT2F6AT.
Anti-human HSPA13 mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human HSPA13 protein 23-471 amino acids purified from E. coli.
Mouse IgG1 heavy chain and k light chain.
Product Science Overview
Heat shock proteins (HSPs) are a family of proteins that are produced by cells in response to stressful conditions. They play a crucial role in protein folding, repair, and degradation, ensuring cellular homeostasis. Among these, the 70kDa heat shock proteins (Hsp70) are highly conserved and ubiquitously expressed across various species, including humans and mice.
The Hsp70 family consists of several members, each with specific functions and localizations within the cell. These proteins are involved in the folding of newly synthesized proteins, the refolding of misfolded or aggregated proteins, and the transport of proteins across cellular membranes . The Hsp70 proteins have three major functional domains:
HSPA13, also known as Heat Shock Protein Family A (Hsp70) Member 13, is a specific member of the Hsp70 family. It is associated with microsomes and plays a role in the processing of cytosolic and secretory proteins, as well as in the removal of denatured or incorrectly-folded proteins . The protein encoded by the HSPA13 gene contains an ATPase domain and has been shown to associate with a ubiquitin-like protein .
The Mouse Anti-Human HSPA13 antibody is a monoclonal antibody produced by immunizing mice with human HSPA13 protein. This antibody is used in various research applications, including:
- Western blotting: To detect HSPA13 protein levels in different samples.
- Immunohistochemistry: To localize HSPA13 within tissues.
- Immunoprecipitation: To isolate HSPA13 and its interacting partners.
The study of HSPA13 and its interactions is significant for understanding cellular stress responses and protein homeostasis. Dysregulation of HSPA13 has been associated with various diseases, including immunodeficiency and cortical dysplasia . Research using the Mouse Anti-Human HSPA13 antibody helps in elucidating the role of HSPA13 in these conditions and can contribute to the development of therapeutic strategies.
