HSF2BP Human

Heat Shock Transcription Factor 2 Binding Protein Human Recombinant
Cat. No.
BT16761
Source
Escherichia Coli.
Synonyms
Heat Shock Transcription Factor 2 Binding Protein, Heat Shock Factor 2 Binding Protein, HSF2BP.
Appearance
Sterile Filtered colorless solution.
Purity
Greater than 85.0% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Shipped with Ice Packs
In Stock
Quick Inquiry

Description

HSF2BP Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 357 amino acids (1-334 a.a) and having a molecular mass of 40kDa.
HSF2BP is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Product Specs

Introduction
HSF2BP, also known as HSF2 binding protein, interacts with HSF2. This interaction occurs between the trimerization domain of HSF2 and the amino-terminal hydrophilic region of HSF2BP, which contains two leucine zipper motifs. Thus, HSF2BP plays a role in regulating the activation of HSF2.
Description
Recombinant human HSF2BP protein, expressed in E. coli, is a single, non-glycosylated polypeptide chain consisting of 357 amino acids (residues 1-334) with a molecular weight of 40 kDa. The protein includes a 23 amino acid His-tag at the N-terminus and is purified using proprietary chromatographic techniques.
Physical Appearance
A sterile, colorless, and transparent solution.
Formulation
The HSF2BP protein solution is provided at a concentration of 0.5 mg/ml and contains 20 mM Tris-HCl buffer (pH 8.0), 0.2 M NaCl, 30% glycerol, and 2 mM DTT.
Stability
For short-term storage (2-4 weeks), the protein should be stored at 4°C. For longer storage, it is recommended to store the protein frozen at -20°C. The addition of a carrier protein (0.1% HSA or BSA) is recommended for long-term storage. It is important to avoid repeated freeze-thaw cycles to maintain protein stability.
Purity
The purity of the protein is greater than 85%, as determined by SDS-PAGE analysis.
Synonyms
Heat Shock Transcription Factor 2 Binding Protein, Heat Shock Factor 2 Binding Protein, HSF2BP.
Source
Escherichia Coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSMGEAGAA EEACRHMGTK EEFVKVRKKD LERLTTEVMQ IRDFLPRILN GEVLESFQKL KIVEKNLERK EQELEQLKMD CEHFKARLET VQADNIREKK EKLALRQQLN EAKQQLLQQA EYCTEMGAAA CTLLWGVSSS EEVVKAILGG DKALKFFSIT GQTMESFVKS LDGDVQELDS DESQFVFALA GIVTNVAAIA CGREFLVNSS RVLLDTILQL LGDLKPGQCT KLKVLMLMSL YNVSINLKGL KYISESPGFI PLLWWLLSDP DAEVCLHVLR LVQSVVLEPE VFSKSASEFR SSLPLQRILA MSKSRNPRLQ TAAQELLEDL RTLEHNV.

Product Science Overview

Introduction

Heat Shock Transcription Factor 2 Binding Protein (HSF2BP) is a protein coding gene that plays a crucial role in various cellular processes, particularly in response to stress conditions. This protein is involved in the regulation of heat shock transcription factors, which are essential for the activation of heat shock response genes under stress conditions.

Gene and Protein Structure

HSF2BP is encoded by the HSF2BP gene, which is located on chromosome 21 in humans . The protein itself is characterized by the presence of leucine zipper motifs, which are crucial for its interaction with other proteins, including Heat Shock Transcription Factor 2 (HSF2) . The interaction between HSF2BP and HSF2 occurs through the trimerization domain of HSF2 and the amino terminal hydrophilic region of HSF2BP .

Function and Mechanism

HSF2BP is primarily known for its role in modulating the activation of HSF2. It associates with HSF2 and may influence its activation during stress conditions . Additionally, HSF2BP is involved in meiotic recombination, particularly in the repair of double-strand breaks (DSBs) during meiosis . It modulates the localization of recombinases DMC1 and RAD51 to meiotic DSB sites through its interaction with BRCA2 . This function is essential for proper homologous recombination, synapsis, and crossover formation, which are critical for the progression of meiosis and fertility .

Clinical Significance

Mutations or dysregulation of HSF2BP have been associated with various disorders. Notably, it has been linked to Premature Ovarian Failure 19 and Primary Ovarian Insufficiency . These conditions highlight the importance of HSF2BP in reproductive health and its potential role in fertility-related disorders.

Research and Applications

The recombinant form of HSF2BP (Human Recombinant) is used in various research applications to study its function and interactions. Understanding the role of HSF2BP in stress response and meiotic recombination can provide insights into the mechanisms underlying various genetic disorders and potential therapeutic targets.

Quick Inquiry

Personal Email Detected
Please use an institutional or corporate email address for inquiries. Personal email accounts ( such as Gmail, Yahoo, and Outlook) are not accepted. *

Category

Service

THE BIOTEK
THE BioTek is a global biotech company offering highly purified proteins for research in cancer, apoptosis, development, endocrinology, immunology, neuroscience, proteases, and stem cells.
  • Contact
  • Address: 1925 E Maple Ave, El Segundo, CA 90245 United States
  • Phone : +1 201-285-7826
  • Email : info@thebiotek.com
  • Hours : Mon.-Fri. 9:00 AM - 5:00 PM
© Copyright 2024 Thebiotek. All Rights Reserved.