HSBP1L1 Human
Description
HSBP1L1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Product Science Overview
Heat Shock Factor Binding Protein 1-Like 1 (HSBP1L1) is a protein that plays a significant role in the cellular response to stress, particularly heat shock. This protein is part of a larger family of heat shock proteins and factors that are crucial for maintaining cellular homeostasis under stressful conditions.
HSBP1L1 is a protein-coding gene that is predicted to enable transcription corepressor activity. It is involved in cellular heat acclimation and is active in both the cytosol and nucleus . The protein binds to Heat Shock Factor 1 (HSF1), a transcription factor that is central to the heat shock response. During this response, HSF1 undergoes a conformational change from an inert, non-DNA-binding monomer to an active, functional trimer .
The heat shock response is a highly conserved cellular defense mechanism that is activated by various stress factors, including elevated temperatures, oxidizing agents, toxins, heavy metals, and infective microbes. The primary role of this response is to maintain protein homeostasis (proteostasis) by upregulating the expression of heat shock proteins (HSPs), also known as molecular chaperones . These proteins assist in the refolding or degradation of damaged intracellular proteins, thereby protecting the cell from proteotoxic stress.
HSBP1L1, by binding to HSF1, plays a regulatory role in this process. It helps modulate the activity of HSF1, ensuring that the heat shock response is appropriately activated and terminated. This regulation is crucial for preventing the detrimental effects of prolonged stress responses, which can lead to cellular damage and disease.
The heat shock response, and by extension the role of HSBP1L1, is vital for the survival of cells under stressful conditions. This response is not only important for protecting cells from acute stress but also plays a role in various physiological and pathological processes. These include differentiation, immune response, multidrug resistance, ageing, neurodegenerative diseases, and cancer .
Human recombinant HSBP1L1 is used in research to study its role in the heat shock response and its potential implications in various diseases. Understanding the function and regulation of HSBP1L1 can provide insights into the development of therapeutic strategies for conditions associated with proteotoxic stress, such as neurodegenerative diseases and cancer.
