HPRT PAT1D9AT Antibody
Hypoxanthine-Guanine Phosphoribosyltransferase , EC 2.4.2.8, HGPRT, HGPRTase, HPRT, HPRT1.
Description
Product Specs
Hypoxanthine-Guanine Phosphoribosyltransferase , EC 2.4.2.8, HGPRT, HGPRTase, HPRT, HPRT1.
HPRT antibody was purified from mouse ascitic fluids by protein-A affinity chromatography.
PAT1D9AT.
Anti-human HPRT mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human HPRT amino acids 1-218 purified from E. coli.
Mouse IgG2b heavy chain and κ light chain.
Product Science Overview
HGPRT is vital for maintaining the balance of purine nucleotides in cells. It helps in recycling purines, which are necessary for DNA and RNA synthesis. Deficiency in HGPRT activity can lead to severe metabolic disorders such as Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome . Lesch-Nyhan syndrome is characterized by hyperuricemia, hyperuricaciduria, and severe neurological symptoms, including self-mutilation behaviors .
The Clone PAT1D9AT is a monoclonal antibody derived from the hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human HGPRT amino acids 1-218 purified from E. coli . This antibody is specifically designed to target and bind to human HGPRT, making it a valuable tool for research and diagnostic purposes.
- Research: The Clone PAT1D9AT antibody is used in various research applications to study the function and regulation of HGPRT in different biological systems. It helps in understanding the enzyme’s role in purine metabolism and its implications in metabolic disorders.
- Diagnostics: This antibody can be used in diagnostic assays to detect HGPRT levels in biological samples. It is particularly useful in diagnosing conditions related to HGPRT deficiency, such as Lesch-Nyhan syndrome.
- Therapeutics: Research involving HGPRT and its inhibitors can lead to the development of therapeutic strategies for diseases caused by purine metabolism disorders.
