Sterile filtered colorless solution.
Hippocalcin-like protein 1 (HPCAL1) is a member of the neuronal calcium sensor protein family. This protein is highly similar to human hippocalcin and nearly identical to rat and mouse hippocalcin-like 1 proteins . It plays a crucial role in the calcium-dependent regulation of rhodopsin phosphorylation and is significant in neuronal signaling within the central nervous system .
The HPCAL1 gene is located on chromosome 2 in humans (2p25.1) and chromosome 12 in mice . The gene produces two alternatively spliced transcript variants with multiple polyadenylation sites . The protein encoded by this gene is involved in various cellular processes, particularly those related to calcium signaling.
HPCAL1 is involved in the regulation of several cellular processes:
Recent studies have highlighted the role of HPCAL1 in cancer, particularly non-small cell lung carcinoma (NSCLC). HPCAL1 has been reported to regulate cancer growth by activating LDHA (Lactate Dehydrogenase A), which promotes the growth of NSCLC . Knockdown of HPCAL1 has shown to inhibit NSCLC cell growth and tumor growth in vivo .
The discovery of HPCAL1’s role in cancer opens new avenues for research and potential therapeutic interventions. By targeting HPCAL1, it may be possible to develop new treatments for cancers where this protein plays a critical role.