HEPACAM2 Human
HEPACAM2 Human Recombinant
Cat. No.
BT14791
Source
Escherichia Coli.
Synonyms
HEPACAM family member 2 isoform 1, MIKI, HEPACAM family member 2, Mitotic kinetics regulator, HEPACAM2, UNQ305/PRO346.
Appearance
Sterile Filtered colorless solution.
Purity
Greater than 85.0% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description
HEPACAM2 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 343 amino acids (32-351) and having a molecular mass of 37.9 kDa.
HEPACAM2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
HEPACAM2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Introduction
HEPACAM2 plays a crucial role in centrosome maturation during prometaphase. After being PARsylated by TNKS, HEPACAM2 moves from the Golgi apparatus to mitotic centrosomes, where it contributes to the formation of robust microtubules. These microtubules are essential for the rapid movement of chromosomes.
Description
Recombinant human HEPACAM2, expressed in E. coli, is a single, non-glycosylated polypeptide chain. It consists of 343 amino acids (residues 32-351), with a molecular weight of 37.9 kDa. The protein includes a 23 amino acid His-tag at the N-terminus and is purified using proprietary chromatographic techniques.
Physical Appearance
A clear and colorless solution, sterilized by filtration.
Formulation
The HEPACAM2 solution is provided at a concentration of 1 mg/ml in a buffer containing 20 mM Tris-HCl (pH 8.0), 0.4 M Urea, and 10% glycerol.
Stability
For short-term storage (2-4 weeks), the product can be stored at 4°C. For longer storage, it is recommended to freeze the product at -20°C. Adding a carrier protein (0.1% HSA or BSA) is recommended for long-term storage. Avoid repeated freezing and thawing.
Purity
The purity of the protein is greater than 85.0% as determined by SDS-PAGE analysis.
Synonyms
HEPACAM family member 2 isoform 1, MIKI, HEPACAM family member 2, Mitotic kinetics regulator, HEPACAM2, UNQ305/PRO346.
Source
Escherichia Coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSLKVTVPS HTVHGVRGQA LYLPVHYGFH TPASDIQIIW LFERPHTMPK YLLGSVNKSV VPDLEYQHKF TMMPPNASLL INPLQFPDEG NYIVKVNIQG NGTLSASQKI QVTVDDPVTK PVVQIHPPSG AVEYVGNMTL TCHVEGGTRL AYQWLKNGRP VHTSSTYSFS PQNNTLHIAP VTKEDIGNYS CLVRNPVSEM ESDIIMPIIY YGPYGLQVNS DKGLKVGEVF TVDLGEAILF DCSADSHPPN TYSWIRRTDN TTYIIKHGPR LEVASEKVAQ KTMDYVCCAY NNITGRQDET HFTVIITSVG LEKLAQKGKS LSP.
Product Science Overview
Structure and Function
HEPACAM2 is required during prometaphase for centrosome maturation. Following poly-ADP-ribosylation (PARsylation) by TNKS, this protein translocates from the Golgi apparatus to mitotic centrosomes. It plays a key role in the formation of robust microtubules, which are essential for the prompt movement of chromosomes during cell division .
Clinical Significance
Recombinant HEPACAM2
Applications in Research
The recombinant HEPACAM2 protein is used in various applications, including:
Potential for Future Research
Given its remarkable specificity, high expression, presence in early disease, and extracellular secretion, HEPACAM2 holds promise as a diagnostic marker for early SCLC detection. Further investigation into its role in the pathobiology of SCLC could lead to new therapeutic strategies and improved patient outcomes .
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