GULP1 Human
GULP1 Human Recombinant
Cat. No.
BT14031
Source
Escherichia Coli.
Synonyms
GULP, Engulfment Adaptor PTB Domain Containing 1, PTB
Domain Adapter Protein CED-6, Cell Death Protein 6 Homolog, CED6, GULP, PTB Domain Adaptor Protein
CED-6 Engulfment Adapter Protein,
Protein GULP, CED-6.
Appearance
Sterile
filtered colorless solution.
Purity
Greater
than 95.0% as determined by SDS-PAGE.
Usage
THE BioTeks products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Shipped with Ice Packs 
In Stock 
Description
GULP1 Human Recombinant produced in E. coli is a single,
non-glycosylated polypeptide chain containing 327 amino acids (1-304a.a) and
having a molecular mass of 36.9kDa.
GULP1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
GULP1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Introduction
The PTB domain-containing engulfment adapter protein 1 (GULP1) is an evolutionarily conserved adapter protein that plays a critical role in facilitating the efficient phagocytosis of apoptotic cells by phagocytes. GULP1 also contributes to the regulation of cellular glycosphingolipid and cholesterol transport. Additionally, GULP1 is believed to be involved in the internalization and endosomal trafficking of various LRP1 ligands, including PSAP. Elevated levels of GULP1 in the cytoplasm have been associated with increased cellular levels of GTP-bound ARF6.
Description
Recombinant human GULP1, expressed in E. coli, is a single, non-glycosylated polypeptide chain. It consists of 327 amino acids (1-304a.a), with a molecular weight of 36.9 kDa. The protein includes a 23 amino acid His-tag fused at the N-terminus and is purified using proprietary chromatographic techniques.
Physical Appearance
A sterile, colorless solution.
Formulation
The GULP1 protein solution (0.5 mg/ml) is supplied in a buffer containing 20 mM Tris-HCl (pH 8.0), 0.15 M NaCl, 50% glycerol, and 2 mM DTT.
Stability
For short-term storage (up to 2-4 weeks), the product can be stored at 4°C. For extended storage, it is recommended to freeze the product at -20°C. To ensure long-term stability during frozen storage, the addition of a carrier protein (0.1% HSA or BSA) is advised. Avoid subjecting the product to multiple freeze-thaw cycles.
Purity
The purity of the protein is determined to be greater than 95.0% by SDS-PAGE analysis.
Synonyms
GULP, Engulfment Adaptor PTB Domain Containing 1, PTB
Domain Adapter Protein CED-6, Cell Death Protein 6 Homolog, CED6, GULP, PTB Domain Adaptor Protein
CED-6 Engulfment Adapter Protein,
Protein GULP, CED-6.
Source
Escherichia Coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSMNRAFSR KKDKTWMHTP EALSKHFIPY NAKFLGSTEV EQPKGTEVVR
DAVRKLKFAR HIKKSEGQKI PKVELQISIY GVKILEPKTK EVQHNCQLHR ISFCADDKTD KRIFTFICKD
SESNKHLCYV FDSEKCAEEI TLTIGQAFDL AYRKFLESGG KDVETRKQIA GLQKRIQDLE TENMELKNKV
QDLENQLRIT QVSAPPAGSM TPKSPSTDIF DMIPFSPISH QSSMPTRNGT QPPPVPSRST EIKRDLFGAE
PFDPFNCGAA DFPPDIQSKL DEMQEGFKMG LTLEGTVFCL DPLDSRC.
Product Science Overview
Gene Information
Protein Information
- Protein Class: Plasma proteins
- Predicted Location: Membrane, Intracellular
- Protein Function: GULP1 functions as an adapter protein required for the efficient phagocytosis of apoptotic cells. It modulates cellular glycosphingolipid and cholesterol transport and may play a role in the internalization and endosomal trafficking of various LRP1 ligands .
Recombinant GULP1
The recombinant form of GULP1 is produced in Escherichia coli and is a single, non-glycosylated polypeptide chain containing 327 amino acids with a molecular mass of 36.9 kDa . It is fused to a 23 amino acid His-tag at the N-terminus and purified by proprietary chromatographic techniques .
- Formulation: GULP1 protein solution containing 20 mM Tris-HCl buffer (pH 8.0), 0.15 M NaCl, 50% glycerol, and 2 mM DTT .
- Purity: Greater than 95.0% as determined by SDS-PAGE .
- Stability: Store at 4°C if used within 2-4 weeks. For long-term storage, it is recommended to add a carrier protein (0.1% HSA or BSA) and store frozen at -20°C .
Biological Processes
GULP1 is involved in several biological processes, including:
- Apoptosis: Facilitates the engulfment of apoptotic cells by phagocytes .
- Lipid Transport: Modulates cellular glycosphingolipid and cholesterol transport .
- Phagocytosis: Essential for the efficient phagocytosis of apoptotic cells .
- Transport: Plays a role in the internalization and endosomal trafficking of various LRP1 ligands .
GULP1’s role in these processes makes it a crucial protein for maintaining cellular homeostasis and efficient cellular function.
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