GOSR2 Human

Golgi SNAP Receptor Complex Member 2 Human Recombinant
Cat. No.
BT13349
Source
E.coli.
Synonyms
Bos1, EPM6, GS27, Membrin, Golgi SNAP receptor complex member 2, 27 kDa Golgi SNARE protein, GOSR2.
Appearance
Sterile Filtered colorless solution.
Purity
Greater than 85% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description

GOSR2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 213 amino acids (1-190a.a) and having a molecular mass of 24.6kDa. GOSR2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Product Specs

Introduction
Golgi SNAP receptor complex member 2 isoform A (GOSR2), a member of the SNARE protein family, plays a crucial role in intracellular trafficking. SNARE proteins facilitate the transport of molecules between the endoplasmic reticulum and the Golgi apparatus, as well as between different Golgi subcompartments. Notably, GOSR2 is situated in close proximity to a genetic region associated with familial essential hypertension. This suggests its potential involvement in the development of this condition. Structurally, GOSR2 proteins are integrated into membranes with their functional domains facing the cytoplasm.
Description
Recombinant human GOSR2, expressed in E. coli, is a non-glycosylated polypeptide chain. This single-chain protein consists of 213 amino acids, spanning from position 1 to 190a.a, with a molecular weight of 24.6 kDa. For purification purposes, a 23-amino acid His-tag is fused to the N-terminus. The purification process involves proprietary chromatographic techniques.
Physical Appearance
Clear, colorless solution, sterilized by filtration.
Formulation
The GOSR2 protein is supplied in a solution at a concentration of 0.25 mg/ml. The solution is buffered with 20 mM Tris-HCl at pH 8.0 and contains 1 M urea and 10% glycerol.
Stability
For short-term storage (2-4 weeks), the product can be stored at 4°C. For extended storage, it is recommended to freeze the product at -20°C. Adding a carrier protein like HSA or BSA (0.1%) is advisable for long-term storage. Repeated freezing and thawing should be avoided.
Purity
The purity of the GOSR2 protein is greater than 85%, as assessed by SDS-PAGE analysis.
Synonyms
Bos1, EPM6, GS27, Membrin, Golgi SNAP receptor complex member 2, 27 kDa Golgi SNARE protein, GOSR2.
Source
E.coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSMDPLFQQ THKQVHEIQS CMGRLETADK QSVHIVENEI QASIDQIFSR LERLEILSSK EPPNKRQNAR LRVDQLKYDV QHLQTALRNF QHRRHAREQQ ERQREELLSR TFTTNDSDTT IPMDESLQFN SSLQKVHNGM DDLILDGHNI LDGLRTQRLT LKGTQKKILD IANMLGLSNT VMRLIEKRAF QDK.

Product Science Overview

Function and Importance

GOSR2 is involved in the transport of proteins from the cis/medial-Golgi to the trans-Golgi network . This process is essential for the proper functioning of the Golgi apparatus, which is responsible for modifying, sorting, and packaging proteins and lipids for secretion or delivery to other organelles . The protein encoded by GOSR2 is a part of the SNARE (Soluble NSF Attachment Protein Receptor) complex, which mediates the docking and fusion of vesicles originating from the endoplasmic reticulum (ER) with the Golgi apparatus .

Genetic and Clinical Significance

Mutations in the GOSR2 gene have been linked to several disorders, including North Sea progressive myoclonus epilepsy (NS-PME), a rare subtype of progressive myoclonus epilepsy prevalent in northern Europe . Additionally, due to its chromosomal location and trafficking function, GOSR2 may be involved in familial essential hypertension . The gene has three transcript variants encoding different isoforms, which adds to its functional diversity .

Research and Applications

The study of GOSR2 and its recombinant forms is significant for understanding the molecular mechanisms underlying vesicular trafficking and its associated disorders. Human recombinant GOSR2 is used in various research applications, including the study of protein transport, Golgi apparatus function, and the development of therapeutic interventions for related genetic disorders.

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