GORASP2 Human

The GORASP2 gene is located on chromosome 2q31.1 and encodes a protein of approximately 55 kDa . The protein consists of 454 amino acids and is a member of the Golgi reassembly stacking protein family . GORASP2 shares significant homology with another Golgi protein, GORASP1 (GRASP65), and both proteins play complementary roles in Golgi structure and function .

GORASP2 is primarily involved in the stacking of Golgi cisternae, which are the flattened membrane-bound compartments that make up the Golgi apparatus . The stacking of these cisternae is essential for the formation of the Golgi ribbon, a continuous network of Golgi stacks that is crucial for efficient protein trafficking and processing .

During cell division (mitosis and meiosis), the Golgi apparatus undergoes fragmentation, and GORASP2 plays a critical role in the reassembly of Golgi stacks after cell division . This reassembly process ensures that the Golgi apparatus can resume its normal functions in the daughter cells.

Additionally, GORASP2 has been implicated in the intracellular transport of specific transmembrane proteins, such as transforming growth factor alpha (TGFA) . It may also function as a molecular chaperone, assisting in the proper folding and assembly of proteins within the Golgi .

Mutations or dysregulation of the GORASP2 gene have been associated with several diseases, including congenital disorders of glycosylation and hyperinsulinemic hypoglycemia . These conditions highlight the importance of GORASP2 in maintaining normal cellular functions and protein processing.

Recombinant human GORASP2 is used in various research applications to study Golgi structure and function. By expressing and purifying this protein in a laboratory setting, researchers can investigate its role in Golgi reassembly, protein trafficking, and its interactions with other cellular components .