GNG11 Human

Guanine Nucleotide Binding Protein Gamma 11 Human Recombinant

Cat. No.

BT13154

Source

Escherichia Coli.

Synonyms

GNGT11, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11, GNG11.

Appearance

Sterile Filtered clear solution.

Purity

Greater than 90% as determined by SDS-PAGE.

Usage

Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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Description

GNG11 Human Recombinant produced in E. coli is. a single polypeptide chain containing 93 amino acids (1-70) and having a molecular mass of 10.6kDa. GNG11 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Product Specs

Introduction

Guanine Nucleotide Binding Protein Gamma 11 (GNG11) is part of the guanine nucleotide-binding protein (G protein) gamma family and encodes a protein found in the cell membrane that is anchored to lipids. G proteins function as modulators or transducers in various signaling systems across membranes. GNG11 undergoes carboxyl-terminal processing.

Description

Recombinant human GNG11, produced in E. coli, is a single polypeptide chain comprising 93 amino acids (1-70) with a molecular weight of 10.6 kDa. A 23 amino acid His-tag is fused to the N-terminus of GNG11. Purification is achieved using proprietary chromatographic techniques.

Physical Appearance

Clear, sterile, and filtered solution.

Formulation

The GNG11 solution (1mg/ml) is supplied in 20mM Tris-HCl buffer (pH 8.0), containing 0.15M NaCl, 10% glycerol, and 1mM DTT.

Stability

For short-term storage (2-4 weeks), keep at 4°C. For extended storage, freeze at -20°C. Adding a carrier protein (0.1% HSA or BSA) is recommended for long-term storage. Avoid repeated freeze-thaw cycles.

Purity

Purity exceeds 90% as determined by SDS-PAGE analysis.

Synonyms

GNGT11, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11, GNG11.

Source

Escherichia Coli.

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGSMPALHIE DLPEKEKLKM EVEQLRKEVK LQRQQVSKCS EEIKNYIEER SGEDPLVKGI PEDKNPFKEK GSC.

Product Science Overview

Structure and Function

GNG11 is a lipid-anchored, cell membrane protein that forms part of the heterotrimeric G protein complex. This complex consists of alpha, beta, and gamma subunits. The gamma subunit, including GNG11, is essential for the GTPase activity, the replacement of GDP by GTP, and the interaction with G protein effectors.

Biological Role

GNG11 is involved in the G protein-coupled receptor (GPCR) signaling pathway, which is pivotal for various cellular processes. The protein’s beta and gamma chains are necessary for the GTPase activity, which is crucial for signal transduction. This signaling pathway influences many cellular functions, including growth, differentiation, and metabolism.

Clinical Significance

Decreased expression of the GNG11 gene has been associated with splenic marginal zone lymphomas . This suggests that GNG11 may play a role in the development or progression of certain types of cancer.

Recombinant GNG11

Human recombinant GNG11 is produced using recombinant DNA technology, which involves inserting the GNG11 gene into a suitable expression system to produce the protein in vitro. This recombinant protein can be used for various research purposes, including studying its role in signal transduction and its potential involvement in diseases.

Research and Applications

Research on GNG11 has provided insights into its function and role in cellular signaling. The recombinant form of GNG11 is valuable for studying the protein’s structure, function, and interactions with other molecules. It can also be used in drug discovery and development, particularly in targeting GPCR signaling pathways.

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GNG11 Human

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