GLOD4 Human

Glyoxalase Domain Containing 4 (GLOD4) is a protein encoded by the GLOD4 gene in humans. This protein is part of the glyoxalase family, which plays a crucial role in the detoxification of methylglyoxal, a byproduct of glycolysis. The GLOD4 gene is located on chromosome 17 and is also known by several aliases, including C17orf25, CGI-150, and HC71 .

GLOD4 is a protein-coding gene that enables cadherin binding activity and is located in extracellular exosomes . The protein is involved in various cellular processes, including the innate immune response, protein ubiquitination, and transmembrane transport . It is expressed in multiple tissues, including the heart, brain, liver, kidney, pancreas, and placenta, but is not expressed in skeletal muscle and lung .

The expression of GLOD4 is tissue-specific. It is highly expressed in lymphoid tissue and bone marrow, where it is involved in cell proliferation and the innate immune response . Additionally, it plays a role in spermatid development in the testis and skeletal muscle . The protein is also found in various parts of the brain, including the hippocampal formation, amygdala, and cerebral cortex .

GLOD4 has been associated with early-onset Parkinson’s disease . Research indicates that its expression is decreased in hepatocellular carcinoma samples compared to adjacent non-cancerous liver tissues from the same patients . This suggests that GLOD4 may have a role in cancer biology and could potentially serve as a biomarker for certain diseases.

Recombinant human GLOD4 protein is produced using various expression systems, including bacterial, yeast, and mammalian cells. This recombinant protein is used in research to study its function, interactions, and potential therapeutic applications. It is available from several suppliers and is validated using techniques such as SDS-PAGE and mass spectrometry .