The GIPC2 gene encodes a protein that consists of 315 amino acids . The protein has a central PDZ domain, which is a common structural domain in signaling proteins. This domain allows GIPC2 to interact with other proteins, facilitating various cellular functions. The GIPC2 protein shares a high degree of similarity with other GIPC family members, such as GIPC1, with which it shares 62.0% amino acid identity .
GIPC2 is involved in several cellular processes, including signal transduction and protein trafficking. It is located in extracellular exosomes, which are small vesicles released by cells that play a role in cell communication . The protein’s ability to bind identical proteins suggests it may have a role in forming protein complexes that are essential for its function.
Research has shown that GIPC2 is associated with certain diseases, such as pheochromocytoma, a type of tumor that arises from the adrenal gland . The gene’s expression and function have been studied in various model organisms, including mice. Studies using mouse models have provided insights into the gene’s role in development and disease .
The development of mouse anti-human GIPC2 antibodies has been crucial for research. These antibodies are used to study the protein’s expression and function in human tissues. They are also valuable tools for investigating the role of GIPC2 in diseases and for developing potential therapeutic strategies.