GIPC1 Human
GIPC PDZ Domain Member 1 Human Recombinant
Cat. No.
BT11204
Source
Escherichia Coli.
Synonyms
PDZ domain-containing protein GIPC1, GAIP C-terminus-interacting protein, RGS-GAIP-interacting protein, RGS19-interacting protein 1, Tax interaction protein 2, TIP-2, GIPC1, C19orf3, GIPC, RGS19IP1, NIP, GIPC, IIP-1, SEMCAP, Hs.6454, MGC3774, GLUT1CBP, MGC15889. SYNECTIN, SYNECTIIN.
Appearance
Sterile filtered colorless solution.
Purity
Greater than 95.0% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description
GIPC1 Recombinant Human produced in E.Coli is a single, non-glycosylated polypeptide chain containing 353 amino acids (1-333 a.a) and having a molecular mass of 38.2kDa. The GIPC1 is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
Product Specs
Introduction
GIPC1, a PDZ domain-containing protein, interacts with RGS-GAIP and the viral oncoprotein TAX. TAX activates viral and cellular promoters through interactions with various transcription factors. GIPC1 is primarily located in vesicle clusters near the plasma membrane and plays a role in G protein-coupled signaling pathways. It participates in regulating clathrin-coated vesicular trafficking. Additionally, GIPC1 interacts with membrane-bound Semaphorin F, involved in neuronal axon growth, and regulates the subcellular distribution of M-SemF in the brain.
Description
Recombinant Human GIPC1, produced in E. coli, is a single, non-glycosylated polypeptide chain consisting of 353 amino acids (1-333 a.a). It has a molecular weight of 38.2 kDa. The GIPC1 protein is fused to a 20 amino acid His-Tag at the N-terminus and purified using proprietary chromatographic techniques.
Physical Appearance
A sterile, colorless solution that has been filtered.
Formulation
Human GIPC1 solution (0.5 mg/ml) in a buffer containing 20 mM Tris-HCl (pH 8), 1 mM DTT, 0.1 M NaCl, 1 mM EDTA, and 20% glycerol.
Stability
For short-term storage (2-4 weeks), keep at 4°C. For extended storage, freeze at -20°C. Adding a carrier protein (0.1% HSA or BSA) is recommended for long-term storage. Avoid repeated freeze-thaw cycles.
Purity
Purity exceeds 95.0% as assessed by SDS-PAGE.
Synonyms
PDZ domain-containing protein GIPC1, GAIP C-terminus-interacting protein, RGS-GAIP-interacting protein, RGS19-interacting protein 1, Tax interaction protein 2, TIP-2, GIPC1, C19orf3, GIPC, RGS19IP1, NIP, GIPC, IIP-1, SEMCAP, Hs.6454, MGC3774, GLUT1CBP, MGC15889. SYNECTIN, SYNECTIIN.
Source
Escherichia Coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MPLGLGRRKK APPLVENEEA EPGRGGLGVG EPGPLGGGGS GGPQMGLPPP PPALRPRLVF HTQLAHGSPT GRIEGFTNVK ELYGKIAEAF RLPTAEVMFC TLNTHKVDMD KLLGGQIGLE DFIFAHVKGQ RKEVEVFKSE DALGLTITDN GAGYAFIKRI KEGSVIDHIH LISVGDMIEA INGQSLLGCR HYEVARLLKE LPRGRTFTLK LTEPRKAFDM ISQRSAGGRP GSGPQLGTGR GTLRLRSRGP ATVEDLPSAF EEKAIEKVDD LLESYMGIRD TELAATMVEL GKDKRNPDEL AEALDERLGD FAFPDEFVFD VWGAIGDAKV GRY.
Product Science Overview
Gene and Protein Structure
Function and Mechanism
GIPC1 is primarily involved in the regulation of cell surface receptor expression and trafficking . It acts as a scaffolding protein, meaning it helps organize and stabilize various signaling complexes within the cell. One of the key interactions of GIPC1 is with the C-terminus of RGS-GAIP, a protein involved in the regulation of G protein signaling . GIPC1 is also known to interact with other proteins, contributing to its role in multiple signaling pathways.
Biological Processes
GIPC1 is implicated in several biological processes, including:
- G protein-coupled receptor signaling pathway: GIPC1 plays a role in the signaling pathways mediated by G protein-coupled receptors (GPCRs), which are involved in various physiological responses .
- Regulation of protein stability: GIPC1 helps in maintaining the stability of certain proteins within the cell .
- Endothelial cell migration: GIPC1 is involved in the movement of endothelial cells, which are essential for the formation of new blood vessels .
- Synaptic plasticity: GIPC1 contributes to the regulation of synaptic plasticity, which is crucial for learning and memory .
Clinical Significance
Mutations or dysregulation of the GIPC1 gene have been associated with certain diseases, including:
Research and Applications
Recombinant GIPC1 protein is used in research to study its interactions and functions in cellular processes. Understanding the role of GIPC1 can provide insights into the mechanisms of diseases and potentially lead to the development of therapeutic strategies.
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