GID8 Human
Description
GID8 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Product Science Overview
GID Complex Subunit 8, also known as GID8, is a protein-coding gene that plays a crucial role in various biological processes. It is a part of the GID (Glucose-Induced Degradation) complex, which is a conserved E3 ubiquitin ligase. This complex is involved in regulating glucose metabolism, cell cycle progression, and other essential cellular functions .
The GID complex is a multi-subunit assembly that includes several proteins, with GID8 being one of its critical components. The complex functions as an E3 ubiquitin ligase, which means it helps tag proteins with ubiquitin molecules, marking them for degradation by the proteasome. This process is vital for maintaining cellular homeostasis by removing damaged or unnecessary proteins .
GID8, specifically, is involved in substrate recognition and recruitment within the GID complex. It interacts with other subunits to ensure the proper functioning of the complex. Recent studies have shown that the human GID complex engages two distinct modules for substrate recruitment, dependent on either WDR26 or GID4 .
The GID complex, including GID8, is essential for various cellular processes. It plays a significant role in regulating glucose metabolism, which is crucial for energy production and overall cellular function. Additionally, the complex is involved in cell cycle progression, ensuring that cells divide and proliferate correctly .
Research on GID8 and the GID complex has provided valuable insights into their roles in cellular processes and potential implications in diseases. For instance, mutations or dysregulation of GID8 have been associated with certain disorders, such as Lissencephaly . Understanding the function and regulation of GID8 can help develop therapeutic strategies for related conditions.
In the context of recombinant protein technology, human recombinant GID8 is produced using genetic engineering techniques. This involves inserting the GID8 gene into a suitable expression system, such as bacteria or mammalian cells, to produce the protein in large quantities. Recombinant GID8 can be used in various research applications, including studying its structure, function, and interactions within the GID complex.
