GAS7 Human
Description
GAS7 is fused to 20 amino acid His Tag at N-terminus and purified by proprietary chromatographic techniques.
Product Specs
Product Science Overview
The GAS7 Isoform b is produced in Escherichia coli (E. coli) as a single, non-glycosylated polypeptide chain containing 436 amino acids. It has a molecular mass of approximately 49.8 kDa. The recombinant protein is fused to a 20 amino acid His Tag at the N-terminus, which facilitates its purification through chromatographic techniques .
GAS7 is primarily expressed in the brain and is believed to play a crucial role in the development and maintenance of the nervous system. It is involved in the regulation of neuronal differentiation and neurite outgrowth. The protein has been implicated in various cellular processes, including:
- Cell Growth Arrest: GAS7 is associated with the arrest of cell growth, which is essential for the proper differentiation of cells.
- Neuronal Differentiation: It promotes the differentiation of neuronal cells, contributing to the development of the nervous system.
- Cytoskeletal Organization: GAS7 interacts with the cytoskeleton, influencing cell shape and motility.
The recombinant form of GAS7 Isoform b is used in various research applications, including:
- Neuroscience Research: To study the role of GAS7 in neuronal differentiation and development.
- Cell Biology: To investigate the mechanisms of cell growth arrest and differentiation.
- Drug Development: As a potential target for therapeutic interventions in neurodegenerative diseases and other conditions involving abnormal cell growth.
The recombinant GAS7 Isoform b protein is typically stored at 4°C if it is to be used within 2-4 weeks. For longer-term storage, it is recommended to store the protein at -20°C with the addition of a carrier protein such as 0.1% Human Serum Albumin (HSA) or Bovine Serum Albumin (BSA) to prevent degradation. It is important to avoid multiple freeze-thaw cycles to maintain the protein’s stability and activity .
