FSH
Human Follicle Stimulating Hormone
Cat. No.
BT12533
Source
Urine of post-menopausal women.
Synonyms
Follitropin subunit beta, Follicle-stimulating hormone beta subunit, FSH-beta, FSH-B, Follitropin beta chain, FSH.
Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.
Purity
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Shipped with Ice Packs 
In Stock 
Description
FSH Human is a glycoprotein produced from urine of post-menopausal women and having a total molecular mass of 30,000 Dalton.
FSH is a heterodimeric hormone consisting of 92 amino acids a chain and 111 amino acids b chain.
The FSH is purified by proprietary chromatographic techniques.
FSH is a heterodimeric hormone consisting of 92 amino acids a chain and 111 amino acids b chain.
The FSH is purified by proprietary chromatographic techniques.
Product Specs
Introduction
Follicle stimulating hormone (FSH) plays a crucial role in reproduction. Produced by the pituitary gland, it works alongside luteinizing hormone (LH). In females, FSH stimulates the growth and maturation of ovarian follicles, which contain eggs. As follicles mature, they release inhibin, regulating FSH production. In males, FSH supports the production of androgen-binding protein in the testes, essential for sperm production. FSH impacts both sexes by promoting germ cell maturation. In females, it initiates follicular growth, specifically targeting granulosa cells. FSH levels naturally fluctuate throughout the menstrual cycle, influenced by hormones like inhibin B and estrogen. This intricate feedback system ensures the selection of the most developed follicle for ovulation. Similar to LH, the release of FSH is controlled by pulses of gonadotropin-releasing hormone (GnRH) from the hypothalamus, highlighting the complex interplay of hormones in reproductive processes.
Description
Human FSH, a glycoprotein with a molecular weight of 30,000 Daltons, is extracted and purified from the urine of post-menopausal women. Composed of two amino acid chains (92 in the alpha chain and 111 in the beta chain), FSH is meticulously purified using specialized chromatographic techniques.
Physical Appearance
White, sterile-filtered powder in a freeze-dried (lyophilized) form.
Formulation
The lyophilized FSH is free from any additives.
Solubility
For reconstitution, dissolve the lyophilized Follicle Stimulating Hormone in sterile, pyrogen-free water at a concentration of 2,000 IU per ml. This solution can be further diluted with other aqueous solutions as needed.
Stability
Lyophilized FSH, while stable at room temperature for up to 3 weeks, should be stored in a dry environment below -18°C. After reconstitution, FSH-beta should be kept at 4°C for 2-7 days. For longer storage, freeze at -18°C, ideally with a carrier protein (0.1% HSA or BSA) added. Avoid repeated freezing and thawing to maintain stability.
Synonyms
Follitropin subunit beta, Follicle-stimulating hormone beta subunit, FSH-beta, FSH-B, Follitropin beta chain, FSH.
Source
Urine of post-menopausal women.
Contaminants
Less than: 0.1% hCG, 0.5%TSH, 0.5% LH, 0.5%GH and 0.5%Prl.
Free of HbsAg, antibodies to HIV and HCV.
Free of HbsAg, antibodies to HIV and HCV.
Product Science Overview
Function and Role
FSH is essential for the proper functioning of the ovaries in females and the testes in males. It works in conjunction with luteinizing hormone (LH) to regulate the development, growth, pubertal maturation, and reproductive processes of the body .
- In Females: FSH stimulates the growth of ovarian follicles in the ovary before the release of an egg from one follicle at ovulation. It also increases the production of estrogen .
- In Males: FSH is critical for spermatogenesis, the process of sperm production. It acts on the Sertoli cells of the testes to stimulate sperm production .
FSH Levels and Their Significance
FSH levels vary throughout a person’s life and can be indicative of various health conditions:
- Before Puberty: FSH levels are generally low.
- During Puberty: FSH levels rise, triggering the development of secondary sexual characteristics and the maturation of reproductive organs .
- Reproductive Years: In females, FSH levels fluctuate during the menstrual cycle, with higher levels during the follicular phase and lower levels during the luteal phase .
- Menopause: FSH levels increase significantly as the ovaries’ function declines .
Clinical Importance
FSH levels are often measured to assess fertility, diagnose reproductive disorders, and evaluate pituitary function. Abnormal FSH levels can indicate various conditions:
Quick Inquiry
Personal Email Detected
Please use an institutional or corporate email address for inquiries. Personal email accounts ( such as Gmail, Yahoo, and Outlook) are not accepted. *
