FOSL2 Human
FOS-Like Antigen 2 Human Recombinant
Cat. No.
BT9975
Source
Escherichia Coli.
Synonyms
FOS-Like Antigen 2, FRA-2, FRA2, Fos-Related Antigen 2, FOSL2.
Appearance
Sterile filtered colorless solution.
Purity
Greater than 85.0% as determined by SDS-PAGE.
Usage
Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description
FOSL2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 349 amino acids (1-326 a.a) and having a molecular mass of 37.6kDa.
FOSL2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
FOSL2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Introduction
FOS-Like Antigen 2, also known as FOSL2, is a protein encoded by the FOSL2 gene in humans. The Fos gene family comprises four members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins capable of dimerizing with proteins from the JUN family, forming the AP-1 transcription factor complex. Consequently, FOS proteins are implicated in regulating cell proliferation, differentiation, and transformation.
Description
Recombinant human FOSL2, produced in E. coli, is a single, non-glycosylated polypeptide chain consisting of 349 amino acids (1-326 a.a.). It has a molecular weight of 37.6 kDa. A 23-amino acid His-tag is fused to the N-terminus of FOSL2, and the protein is purified using proprietary chromatographic techniques.
Physical Appearance
A clear, sterile-filtered solution.
Formulation
The FOSL2 protein solution has a concentration of 0.5 mg/ml and is supplied in a buffer containing 20mM Tris-HCl (pH 8.0) and 10% glycerol.
Stability
For short-term storage (2-4 weeks), the product can be stored at 4°C. For extended storage, freeze the product at -20°C. Adding a carrier protein (0.1% HSA or BSA) is recommended for long-term storage. Repeated freezing and thawing should be avoided.
Purity
The purity of FOSL2 is determined to be greater than 85.0% by SDS-PAGE analysis.
Synonyms
FOS-Like Antigen 2, FRA-2, FRA2, Fos-Related Antigen 2, FOSL2.
Source
Escherichia Coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSMYQDYPG NFDTSSRGSS GSPAHAESYS SGGGGQQKFR VDMPGSGSAF IPTINAITTS QDLQWMVQPT VITSMSNPYP RSHPYSPLPG LASVPGHMAL PRPGVIKTIG TTVGRRRRDE QLSPEEEEKR RIRRERNKLA AAKCRNRRRE LTEKLQAETE ELEEEKSGLQ KEIAELQKEK EKLEFMLVAH GPVCKISPEE RRSPPAPGLQ PMRSGGGSVG AVVVKQEPLE EDSPSSSSAG LDKAQRSVIK PISIAGGFYG EEPLHTPIVV TSTPAVTPGT SNLVFTYPSV LEQESPASPS ESCSKAHRRS SSSGDQSSDS LNSPTLLAL
Product Science Overview
Gene and Protein Structure
Function
FOSL2 plays a crucial role in regulating various cellular processes, including:
- Cell Proliferation: FOSL2, as part of the AP-1 complex, regulates the expression of genes involved in cell cycle progression and proliferation .
- Differentiation: It is involved in the differentiation of various cell types, including osteoclasts and keratinocytes .
- Transformation: FOSL2 has been implicated in cellular transformation and oncogenesis .
Mechanism of Action
FOSL2 functions primarily as a transcription factor. It binds to specific DNA sequences in the promoter regions of target genes, regulating their transcription . The protein forms heterodimers with JUN family proteins, enhancing its DNA-binding affinity and specificity . This interaction is critical for the formation of the AP-1 transcription factor complex, which regulates the expression of genes involved in various cellular processes .
Clinical Significance
Research and Applications
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