FGFBP Human
Fibroblast Growth Factor Binding Protein 1 Human Recombinant
Cat. No.
BT9682
Source
Escherichia Coli.
Synonyms
Fibroblast Growth Factor Binding Protein 1, FGFBP, HBP17,
17 KDa Heparin-Binding Growth Factor-Binding Protein, 17 KDa HBGF-Binding
Protein, FGF-Binding Protein 1, FGF-BP1, FGFBP-1, FGF-BP, Heparin-Binding
Growth Factor Binding Protein, Fibroblast Growth Factor-Binding Protein 1, Fibroblast
growth factor-binding protein 1.
Appearance
Sterile Filtered colorless clear solution.
Purity
Greater than 85.0% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs,agricultural or pesticidal products, food additives or household chemicals.
Shipped with Ice Packs 
In Stock 
Description
FGFBP Human Recombinant produced in E.Coli is a single, non-glycosylated
polypeptide chain containing 234 amino acids (24-234 a.a) and having a
molecular mass of 26.2kDa.
FGFBP is fused to a 23 amino acid His-tag at N-terminus
& purified by proprietary chromatographic techniques.
Product Specs
Introduction
Fibroblast Growth Factor Binding Protein 1 (FGFBP1) is a secreted protein that binds to and enhances the activity of fibroblast growth factors (FGFs). FGFs are a family of signaling molecules that play critical roles in cell growth, differentiation, and migration. FGFBP1 potentiates the effects of FGFs on target cells, contributing to processes such as cell proliferation, differentiation, and migration. FGFBP1 has been implicated in tumor growth and angiogenesis, and its expression is associated with various cancers, including pancreatic and colorectal adenocarcinoma.
Description
Recombinant human FGFBP is a single, non-glycosylated polypeptide chain produced in E. coli. It consists of 234 amino acids (residues 24-234) and has a molecular weight of 26.2 kDa. The protein contains a 23-amino acid His-tag at the N-terminus to facilitate purification, which is carried out using proprietary chromatographic techniques.
Physical Appearance
Clear, colorless, and sterile-filtered solution.
Formulation
The FGFBP protein is supplied as a 0.25 mg/ml solution in phosphate-buffered saline (pH 7.4) containing 10% glycerol and 1 mM DTT.
Stability
For short-term storage (2-4 weeks), the protein can be stored at 4°C. For extended storage, it is recommended to freeze the protein at -20°C. To further enhance stability during long-term storage, adding a carrier protein (0.1% HSA or BSA) is advisable. Avoid repeated freeze-thaw cycles.
Purity
The purity of the FGFBP protein is greater than 85.0% as determined by SDS-PAGE analysis.
Synonyms
Fibroblast Growth Factor Binding Protein 1, FGFBP, HBP17,
17 KDa Heparin-Binding Growth Factor-Binding Protein, 17 KDa HBGF-Binding
Protein, FGF-Binding Protein 1, FGF-BP1, FGFBP-1, FGF-BP, Heparin-Binding
Growth Factor Binding Protein, Fibroblast Growth Factor-Binding Protein 1, Fibroblast
growth factor-binding protein 1.
Source
Escherichia Coli.
Amino Acid Sequence
MGSSHHHHHH
SSGLVPRGSH MGSKKKVKNG
LHSKVVSEQK DTLGNTQIKQ KSRPGNKGKF VTKDQANCRW AATEQEEGIS LKVECTQLDH EFSCVFAGNP
TSCLKLKDER VYWKQVARNL RSQKDICRYS KTAVKTRVCR KDFPESSLKL VSSTLFGNTK PRKEKTEMSP
REHIKGKETT PSSLAVTQTM ATKAPECVED PDMANQRKTA LEFCGETWSS LCTFFLSIVQ DTSC.
Product Science Overview
Introduction
Fibroblast Growth Factor Binding Protein 1 (FGFBP1), also known as FGF-BP1 or HBp17, is a secreted carrier protein that plays a crucial role in modulating the activity of fibroblast growth factors (FGFs). FGFBP1 enhances the biological effects of FGFs on target cells, influencing various cellular processes such as proliferation, differentiation, and migration .
Structure and Function
FGFBP1 is a non-glycosylated, single polypeptide protein that belongs to the fibroblast growth factor (FGF) superfamily . It acts as a carrier protein, releasing FGFs from the extracellular matrix (ECM) storage and enhancing their mitogenic activity . FGFBP1 is particularly important in tissue repair, angiogenesis, and tumor growth, where it enhances FGF2 signaling .
Biological Roles
FGFBP1 plays a critical role in several biological processes:
- Cell Proliferation: By binding to FGFs, FGFBP1 potentiates their effects on cell proliferation, aiding in tissue growth and repair .
- Differentiation and Migration: FGFBP1 influences cell differentiation and migration, essential for wound healing and embryonic development .
- Angiogenesis: FGFBP1 is involved in the formation of new blood vessels, a process crucial for tissue regeneration and tumor growth .
- Tumor Growth: FGFBP1 acts as an angiogenic switch molecule, promoting tumor growth by enhancing FGF signaling .
Expression Patterns and Tissue Distribution
Regulatory Mechanisms
The expression and activity of FGFBP1 are tightly regulated at multiple levels:
- Transcriptional Regulation: FGFBP1 gene expression is controlled by various transcription factors and signaling pathways .
- Post-translational Modifications: FGFBP1 undergoes post-translational modifications that influence its stability and interaction with FGFs .
- Interaction with ECM: FGFBP1 binds to heparin and other components of the ECM, modulating the availability and activity of FGFs .
Clinical Implications
Alterations in FGFBP1 expression and function are implicated in several diseases:
- Cancer: Overexpression of FGFBP1 is associated with tumor growth and progression in various cancers .
- Neurological Disorders: FGFBP1 is involved in the regulation of neuronal growth and differentiation, with potential implications in neurological disorders .
- Cardiac Arrhythmias: FGFBP1 expression in cardiomyocytes suggests a role in cardiac function and arrhythmias .
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