FGF12 Human
Escherichia Coli.
FGF-12, FGF12, FGF12B, FHF1, Fibroblast growth factor 12, Fibroblast growth factor homologous factor 1, FHF-1, Myocyte-activating factor.
Sterile Filtered White lyophilized (freeze-dried) powder.
Greater than 98.0% as determined by:
(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Description
Fibroblast Growth Factor 12 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 181 amino acids and having a molecular mass of 20.5kDa. The FGF12 is purified by proprietary chromatographic techniques.
Product Specs
FGF-12, FGF12, FGF12B, FHF1, Fibroblast growth factor 12, Fibroblast growth factor homologous factor 1, FHF-1, Myocyte-activating factor.
Escherichia Coli.
MESKEPQLKG IVTRLFSQQG YFLQMHPDGT IDGTKDENSD YTLFNLIPVG LRVVAIQGVK ASLYVAMNGE GYLYSSDVFT PECKFKESVF ENYYVIYSST LYRQQESGRA WFLGLNKEGQ IMKGNRVKKT KPSSHFVPKP IEVCMYREQS LHEIGEKQGR SRKSSGTPTM NGGKVVNQDS T.
Product Science Overview
Fibroblast Growth Factor 12 (FGF12) is a member of the fibroblast growth factor (FGF) family, which consists of heparin-binding proteins involved in a wide range of biological processes, including cell growth, development, and tissue repair. FGF12, in particular, has garnered attention for its role in neural development and function.
FGF12 is a medium-sized single-chain protein with a molecular weight of approximately 22 kDa. It shares a conserved core of about 120 amino acids with other members of the FGF family. The protein functions by binding to and activating high-affinity FGF receptors (FGFRs) on target cells, initiating a signal transduction cascade that involves kinases and transcription factors .
Recombinant human FGF12 is produced using standard biotechnological techniques. The gene encoding FGF12 is cloned into an expression vector, which is then introduced into a host organism, typically E. coli. The host cells express the FGF12 protein, which is subsequently purified using chromatographic methods to achieve high purity and biological activity .
Recombinant FGF12 is widely used in biomedical research to study its role in neural development and its potential therapeutic applications. It is employed in cell culture applications to maintain, expand, and differentiate various cell types. Additionally, FGF12 is used to investigate signaling interactions and pathways involved in neural development and disease .
