Fertirelin

Cat. No.

BT22178

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Synonyms

Appearance

Sterile Filtered White lyophilized (freeze-dried) powder.

Purity

Greater than 97.0% as determined by analysis by RP-HPLC.

Usage

THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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Description

Fertirelin Synthetic is a single, non-glycosylated polypeptide chain containing 9 amino acids, having a molecular mass of 1153.31 Dalton and a Molecular formula of C₅₅H₇₆N₁₆O_12.

Product Specs

Description

Fertirelin Synthetic is a single, non-glycosylated polypeptide chain composed of 9 amino acids. It has a molecular mass of 1153.31 Daltons and a molecular formula of C₅₅H₇₆N₁₆O₁₂.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

The protein has been lyophilized without the addition of any other substances.

Solubility

To reconstitute the lyophilized Fertirelin, it is recommended to dissolve it in sterile 18MΩ-cm H₂O at a concentration of at least 100 µg/ml. This solution can then be further diluted in other aqueous solutions.

Stability

Lyophilized Fertirelin remains stable at room temperature for up to 3 weeks. However, for long-term storage, it is recommended to store it in a dry environment below -18°C. After reconstitution, Fertirelin should be stored at 4°C for a period of 2 to 7 days. For longer storage periods, it is advisable to store it below -18°C. To ensure optimal stability during long-term storage, the addition of a carrier protein (0.1% HSA or BSA) is recommended. Avoid repeated freezing and thawing of the product.

Purity

The purity is determined to be greater than 97.0% based on analysis by RP-HPLC.

Amino Acid Sequence

Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-NHEt.

Product Science Overview

Chemical Structure and Properties

Fertirelin is a synthetic analogue of the natural GnRH. Its chemical formula is C55H76N16O12, and it has a molar mass of 1153.313 g/mol. The structure of Fertirelin includes a series of amino acids arranged in a specific sequence, making it a potent GnRH agonist.

Mechanism of Action

As a GnRH agonist, Fertirelin stimulates the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the anterior pituitary gland. These hormones play crucial roles in regulating reproductive processes, including ovulation and spermatogenesis.

Clinical Uses

Fertirelin has been used in veterinary medicine to treat various reproductive disorders. It was first introduced in 1981 in Japan to address ovarian failure in cattle. The drug has also been used to manage sex hormone-dependent conditions and infertility in women, although its primary application remains in veterinary settings.

Pharmacological Profile

Fertirelin is administered as the acetate salt, known as Fertirelin acetate. It has been shown to effectively induce ovulation and improve fertility in animals by mimicking the natural GnRH and stimulating the release of LH and FSH.

Market Availability

Fertirelin has been marketed in the United Kingdom and Austria, but it may no longer be available in some regions. Despite its limited availability, it remains an important tool in veterinary reproductive medicine.

Research and Development

Research on Fertirelin has focused on its efficacy and safety in inducing ovulation and improving fertility in animals. Studies have demonstrated its ability to stimulate the reproductive axis effectively, making it a valuable asset in veterinary practice.

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Fertirelin

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