FDCSP Human
Description
FDCSP is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Product Science Overview
Follicular Dendritic Cell Secreted Protein (FDCSP) is a small, secreted protein primarily expressed in follicular dendritic cells. These cells are crucial components of the immune system, particularly within the lymphoid tissues. FDCSP plays a significant role in regulating antibody responses and has been implicated in cancer cell migration and invasion.
The FDCSP gene, also known as C4orf7, is located on chromosome 4. The protein encoded by this gene consists of 91 amino acids and has a molecular mass of approximately 10.4 kDa . The human recombinant form of FDCSP is produced in E. coli and is fused to a 23 amino acid His-tag at the N-terminus, which aids in its purification through chromatographic techniques .
FDCSP specifically binds to activated B cells, which are essential for the adaptive immune response. By interacting with these cells, FDCSP helps regulate the generation of antibodies . This regulatory function is vital for maintaining a balanced immune response and preventing overactivation, which could lead to autoimmune disorders.
In addition to its role in the immune system, FDCSP has been found to contribute to tumor metastases. It promotes cancer cell migration and invasion, facilitating the spread of cancer cells to other parts of the body . This dual role in both immune regulation and cancer progression makes FDCSP a protein of significant interest in medical research.
Given its involvement in both immune responses and cancer metastasis, FDCSP is being studied as a potential diagnostic and prognostic biomarker. Its expression levels could provide valuable insights into the state of the immune system and the progression of certain cancers . Furthermore, targeting FDCSP could offer new therapeutic strategies for treating autoimmune diseases and preventing cancer metastasis.
