FCGRT Human
HEK293 Cells.
IgG receptor FcRn large subunit p51, FcRn, IgG Fc fragment receptor transporter alpha chain, Neonatal Fc receptor, Fcgrt, Fcrn.
Sterile Filtered colorless solution.
Greater than 95.0% as determined by SDS-PAGE.
Description
FCGRT Human Recombinant is a glycosylated, polypeptide chain conteining 2 fragments: FCGRT (24-297aa) having a total 280 a.a and a a molecular weigh of 31.1kDa & B2M (21-119 aa) having a total 99 a.a and a a molecular weigh of 11.7kDa.
FCGRT is fused to a 6 a.a his-Tag at C-terminus and is purified by proprietary chromatographic techniques.
Product Specs
IgG receptor FcRn large subunit p51, FcRn, IgG Fc fragment receptor transporter alpha chain, Neonatal Fc receptor, Fcgrt, Fcrn.
HEK293 Cells.
FCGRT
AESHLSLLYH LTAVSSPAPG TPAFWVSGWL GPQQYLSYNS LRGEAEPCGA WVWENQVSWY WEKETTDLRI KEKLFLEAFK ALGGKGPYTL QGLLGCELGP DNTSVPTAKF ALNGEEFMNF DLKQGTWGGD WPEALAISQR WQQQDKAANK ELTFLLFSCP HRLREHLERG RGNLEWKEPP SMRLKARPSS PGFSVLTCSA FSFYPPELQL RFLRNGLAAG TGQGDFGPNS DGSFHASSSL TVKSGDEHHY CCIVQHAGLA QPLRVELESP AKSSHHHHHH.
B2M
IQRTPKIQVY SRHPAENGKS NFLNCYVSGF HPSDIEVDLL KNGERIEKVE HSDLSFSKDW SFYLLYYTEF TPTEKDEYAC RVNHVTLSQP KIVKWDRDM.
Product Science Overview
The Fc fragment of IgG receptor and transporter, also known as the neonatal Fc receptor (FcRn), is a crucial component in the immune system. It plays a significant role in the regulation and transport of immunoglobulin G (IgG) antibodies. This receptor is particularly important for maintaining the homeostasis of IgG and extending its half-life in the bloodstream.
FcRn is a transmembrane glycoprotein with structural homology to MHC class I proteins . It is composed of two subunits: the alpha chain (FCGRT) and beta-2-microglobulin (B2M), forming an MHC class I-like heterodimer . The Fc fragment of IgG binds to FcRn with high affinity at acidic pH (around pH 6) and releases at neutral pH (around pH 7.4) .
FcRn is widely expressed in endothelial and epithelial cells and plays a pivotal role in IgG homeostasis . It rescues IgG from degradation by binding to it in the acidic environment of endosomes and recycling it back to the cell surface, where it is released into the bloodstream at neutral pH . This process significantly extends the half-life of IgG, allowing it to persist in the circulation for an extended period.
One of the critical functions of FcRn is the transplacental transport of IgG from the mother to the fetus. During pregnancy, FcRn mediates the transfer of maternal IgG across the placenta, providing the fetus with passive immunity . This transfer is essential for protecting the newborn from infections during the early stages of life.
Recombinant human FcRn has been utilized in various therapeutic applications. By manipulating the Fc region of IgG, researchers have developed antibodies with altered binding properties to FcRn. These modifications can enhance or reduce the half-life of therapeutic antibodies, depending on the desired outcome . Additionally, FcRn-based therapies are being explored for their potential in treating autoimmune diseases and improving the efficacy of antibody-based drugs .
