FAM84B Human
Family with Sequence Similarity 84, Member B Human Recombinant
Cat. No.
BT8298
Source
Escherichia Coli.
Synonyms
FAM84B, Family with Sequence Similarity 84 Member B, BCMP101, Breast Cancer Membrane-Associated Protein 101, Neurological/Sensory 2, Breast Cancer Membrane Protein 101, NSE2, Protein FAM84B, Protein NSE2.
Appearance
Sterile filtered colorless solution.
Purity
Greater than 85% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description
FAM84B Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 333 amino acids (1-310) and having a molecular mass of 36.9kDa.
FAM84B is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
FAM84B is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Introduction
FAM84B (Family with Sequence Similarity 84, Member B) interacts with CRAF, a downstream effector of RAS. This binding disrupts CRAF's interaction with 14-3-3 proteins and promotes its localization to the cell membrane. Consequently, this leads to increased signaling through the MAPK and mTOR pathways. FAM84B is considered a potential oncogene and a possible target for therapeutic intervention.
Description
Recombinant human FAM84B protein, expressed in E. coli, is a single, non-glycosylated polypeptide chain. It comprises 333 amino acids (residues 1-310) with a molecular weight of 36.9 kDa. The protein includes a 23 amino acid His-tag at the N-terminus and is purified using proprietary chromatographic methods.
Physical Appearance
A clear, colorless solution that is sterile and filtered.
Formulation
The FAM84B solution is provided at a concentration of 0.5 mg/ml in a buffer containing 20mM Tris-HCl (pH 8.0), 10% glycerol, 0.15M NaCl, 1mM DTT, and 0.1mM PMSF.
Stability
For short-term storage (2-4 weeks), keep at 4°C. For longer periods, store frozen at -20°C. Adding a carrier protein (0.1% HSA or BSA) is recommended for long-term storage. Avoid repeated freeze-thaw cycles.
Purity
Purity is greater than 85% as determined by SDS-PAGE analysis.
Synonyms
FAM84B, Family with Sequence Similarity 84 Member B, BCMP101, Breast Cancer Membrane-Associated Protein 101, Neurological/Sensory 2, Breast Cancer Membrane Protein 101, NSE2, Protein FAM84B, Protein NSE2.
Source
Escherichia Coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSMGNQVEK LTHLSYKEVP TADPTGVDRD DGPRIGVSYI FSNDDEDVEP QPPPQGPDGG GLPDGGDGPP PPQPQPYDPR LHEVECSVFY RDECIYQKSF APGSAALSTY TPENLLNKCK PGDLVEFVSQ AQYPHWAVYV GNFQVVHLHR LEVINSFLTD ASQGRRGRVV NDLYRYKPLS SSAVVRNALA HVGAKERELS WRNSESFAAW CRYGKREFKI GGELRIGKQP YRLQIQLSAQ RSHTLEFQSL EDLIMEKRRN DQIGRAAVLQ ELATHLHPAE PEEGDSNVAR TTPPPGRPPA PSSEEEDGEA VAH.
Product Science Overview
References
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