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FAM107B is located on chromosome 10 and is also known by other names such as C10orf45, FLJ45505, and HITS . The gene encodes a protein that consists of 154 amino acids and has a molecular mass of approximately 17.9 kDa . The recombinant form of FAM107B is produced in Escherichia coli (E. coli) and is a single, non-glycosylated polypeptide chain . It is often fused to a 23 amino acid His-tag at the N-terminus to facilitate purification through chromatographic techniques .
FAM107B is predicted to play a role in the sensory perception of sound . It is involved in various cellular processes, including cell proliferation, immune response, and protein ubiquitination . The protein is expressed in multiple tissues, including lymphoid tissue, bone marrow, testis, skeletal muscle, and various immune cells .
Mutations or dysregulation of FAM107B have been linked to several diseases. Notably, it is associated with tibial neuropathy and cataract 13 with adult I phenotype . These associations highlight the potential clinical significance of FAM107B and its importance in maintaining normal physiological functions.
The recombinant form of FAM107B is valuable in research settings. It allows scientists to study the protein’s function, interactions, and role in disease mechanisms. The availability of recombinant FAM107B facilitates various experimental approaches, including structural analysis, functional assays, and therapeutic research.