EXOSC4 Human
Description
Product Specs
Product Science Overview
EXOSC4 is a part of the exosome complex, a multi-protein complex responsible for degrading RNA molecules in eukaryotic cells. The exosome complex plays a vital role in maintaining RNA homeostasis by processing and degrading different types of RNA, including messenger RNA (mRNA), ribosomal RNA (rRNA), and small nuclear RNA (snRNA).
The human recombinant form of EXOSC4 is typically produced in Escherichia coli (E. coli) and is often tagged with a His-tag at the N-terminus to facilitate purification. The recombinant protein corresponds to the amino acids 1-245 of the human EXOSC4 protein .
EXOSC4, as part of the exosome complex, is involved in the 3’ to 5’ degradation of RNA molecules. This degradation process is essential for the regulation of gene expression, RNA quality control, and the removal of defective or unnecessary RNA molecules. The exosome complex, including EXOSC4, ensures that RNA molecules are processed correctly and degraded when they are no longer needed .
EXOSC4 and the exosome complex are critical for various cellular processes, including:
- RNA Processing: The exosome complex processes precursor rRNA, snRNA, and small nucleolar RNA (snoRNA) into their mature forms.
- RNA Degradation: It degrades aberrant or excess RNA molecules, preventing the accumulation of defective RNA that could disrupt cellular functions.
- Gene Expression Regulation: By degrading specific RNA molecules, the exosome complex helps regulate the levels of different RNAs, thereby influencing gene expression .
Recombinant EXOSC4 is widely used in research to study the structure and function of the exosome complex. It is particularly useful in biochemical assays, structural biology studies, and functional analyses. The recombinant form allows researchers to investigate the protein’s properties in a controlled environment, facilitating a deeper understanding of its role in RNA metabolism .
