Eledoisin
(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.
Description
Product Specs
Product Science Overview
Eledoisin has the chemical formula C54H85N13O15S and a molar mass of 1188.40 g/mol . Its amino acid sequence is pGlu-Pro-Ser-Lys-Asp-Ala-Phe-Ile-Gly-Leu-Met-NH2 (where pGlu stands for pyroglutamic acid) . The peptide shares a common C-terminal sequence with other tachykinins, such as Substance P, which is Phe-Xxx-Gly-Leu-Met-NH2 .
Eledoisin was discovered during the study of the salivary glands of certain octopus species. Researchers found that this peptide exhibited significant biological activity, particularly in its ability to cause vasodilation and increase capillary permeability . These properties made it a subject of interest for further pharmacological studies.
Eledoisin exhibits a wide range of activities, including:
- Vasodilation: It is a potent vasodilator, meaning it can widen blood vessels, which helps to increase blood flow.
- Hypertension: It has been observed to cause a temporary increase in blood pressure.
- Smooth Muscle Stimulation: Eledoisin can stimulate extravascular smooth muscle, which is muscle found outside of blood vessels .
These activities are similar to those of other tachykinins, such as Substance P, Neurokinin A (NKA), and Neurokinin B (NKB), which have been more extensively studied in mammals .
Due to its potent biological effects, eledoisin has been studied for various potential applications. Its ability to cause vasodilation and increase capillary permeability makes it a candidate for research in cardiovascular diseases and conditions involving impaired blood flow . Additionally, its role in stimulating smooth muscle has implications for gastrointestinal and respiratory research.
