Elcatonin
(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.
Description
Product Specs
Ser-Asn-Leu-Ser-Thr-Asu-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Val-Gly-Ala-Gly-Thr-Pro-NH2.
Product Science Overview
Elcatonin is a peptide hormone with the chemical formula C148H244N42O47 and a molar mass of approximately 3363.83 g/mol . The modification from eel calcitonin involves changing the disulfide (S-S) bond into a more stable carbon-nitrogen (C-N) bond . This alteration helps in maintaining the structural integrity of the molecule, making it more resistant to enzymatic degradation.
Elcatonin functions similarly to natural calcitonin by inhibiting osteoclast activity, which are the cells responsible for bone resorption. By reducing the activity of osteoclasts, elcatonin helps in decreasing the breakdown of bone tissue, leading to a reduction in the release of calcium from bones into the bloodstream . This action is particularly beneficial in conditions characterized by excessive bone resorption, such as osteoporosis and Paget’s disease.
Elcatonin is primarily used as an anti-parathyroid agent . It is effective in treating conditions that involve high levels of calcium in the blood (hypercalcemia), such as:
- Osteoporosis: A condition where bones become weak and brittle.
- Paget’s Disease: A chronic disorder that can result in enlarged and misshapen bones.
- Hypercalcemia: Elevated calcium levels in the blood, which can be due to various underlying conditions.
By lowering blood calcium levels, elcatonin helps in managing these conditions and preventing complications associated with high calcium levels, such as kidney stones and cardiovascular issues.
The pharmacokinetics of elcatonin, including its absorption, distribution, metabolism, and excretion, are not extensively documented. However, like other peptide hormones, it is likely to be administered via injection to avoid degradation in the gastrointestinal tract. The stability conferred by the C-N bond modification suggests a longer half-life compared to natural calcitonin, allowing for less frequent dosing .
Elcatonin is generally well-tolerated, but like all medications, it can have side effects. Common side effects may include:
- Nausea and vomiting
- Flushing
- Injection site reactions
It is important for patients to be monitored for any adverse reactions, especially if they have a history of allergies to peptide hormones or other components of the formulation.
