ELAVL2 Human

ELAV Like Neuron-Specific RNA Binding Protein 2 Human Recombinant
Cat. No.
BT6300
Source
Escherichia Coli.
Synonyms
ELAV Like Neuron-Specific RNA Binding Protein 2, HUB, ELAV (Embryonic Lethal, Abnormal Vision, Drosophila)-Like 2 (Hu Antigen B), Nervous System-Specific RNA-Binding Protein Hel-N1, Hu-Antigen B, HELN1, ELAV (Embryonic Lethal, Abnormal Vision, Drosophila)-Like 2, ELAV-Like Neuronal Protein 1 Isoform Hel-N2, ELAV-Like Neuronal Protein 1, ELAV-Like Protein 2, Hu Antigen B, HEL-N1, ELAV-like protein 2, ELAV-like neuronal protein 1, Hu-antigen B.
Appearance
Sterile filtered colorless solution.
Purity
Greater than 85% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Shipped with Ice Packs
In Stock
Quick Inquiry

Description

ELAVL2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 369 amino acids (1-346 a.a) and having a molecular mass of 40.4kDa.
ELAVL2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Product Specs

Introduction
ELAV Like Neuron-Specific RNA Binding Protein 2, also known as ELAVL2 is a neural-specific RNA-binding protein recognized for its ability to bind to several 3' UTRs, including its own and those of FOS and ID. ELAVL2 identifies a GAAA motif in the RNA. Contagious pustular dermatitis is one disease associated with ELAVL2.
Description
Recombinant human ELAVL2, produced in E. coli, is a single, non-glycosylated polypeptide chain containing 369 amino acids (amino acids 1-346). It has a molecular mass of 40.4 kDa.

ELAVL2 is fused to a 23 amino acid His-tag at the N-terminus and purified using proprietary chromatographic techniques.
Physical Appearance
Sterile, colorless solution.
Formulation
ELAVL2 protein solution (0.5 mg/mL) in phosphate buffered saline (pH 7.4), 30% glycerol, and 1 mM DTT.
Stability
For short-term storage (2-4 weeks), store at 4°C. For longer storage, freeze at -20°C. Adding a carrier protein (0.1% HSA or BSA) is recommended for long-term storage. Avoid repeated freeze-thaw cycles.
Purity
Purity determined by SDS-PAGE is greater than 85%.
Synonyms
ELAV Like Neuron-Specific RNA Binding Protein 2, HUB, ELAV (Embryonic Lethal, Abnormal Vision, Drosophila)-Like 2 (Hu Antigen B), Nervous System-Specific RNA-Binding Protein Hel-N1, Hu-Antigen B, HELN1, ELAV (Embryonic Lethal, Abnormal Vision, Drosophila)-Like 2, ELAV-Like Neuronal Protein 1 Isoform Hel-N2, ELAV-Like Neuronal Protein 1, ELAV-Like Protein 2, Hu Antigen B, HEL-N1, ELAV-like protein 2, ELAV-like neuronal protein 1, Hu-antigen B.
Source
Escherichia Coli.
Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGSMETQLSN GPTCNNTANG PTTINNNCSS PVDSGNTEDS KTNLIVNYLP QNMTQEELKS LFGSIGEIES CKLVRDKITG QSLGYGFVNY IDPKDAEKAI NTLNGLRLQT KTIKVSYARP SSASIRDANL YVSGLPKTMT QKELEQLFSQ YGRIITSRIL VDQVTGISRG VGFIRFDKRI EAEEAIKGLN GQKPPGATEP ITVKFANNPS QKTNQAILSQ LYQSPNRRYP GPLAQQAQRF RFSPMTIDGM TSLAGINIPG HPGTGWCIFV YNLAPDADES ILWQMFGPFG AVTNVKVIRD FNTNKCKGFG FVTMTNYDEA AMAIASLNGY RLGDRVLQVS FKTNKTHKA.

Product Science Overview

Gene and Protein Structure

The ELAVL2 gene encodes a protein consisting of 359 amino acids . This protein shows significant similarity to the product of the Drosophila elav gene, which is crucial for the proper development of the central nervous system in flies . The human ELAVL2 protein binds to AU-rich elements in the 3’ untranslated regions (3’ UTRs) of target mRNAs, thereby regulating gene expression post-transcriptionally .

Function and Mechanism

ELAVL2 is primarily expressed in neurons and localizes to the cytoplasm . It binds to several 3’ UTRs, including its own, as well as those of FOS, ID, and POU5F1 . The protein recognizes a GAAA motif in the RNA . By binding to these regions, ELAVL2 plays a critical role in the regulation of mRNA stability and translation, which are essential processes for neuronal function and development .

Role in Neurodevelopment and Disorders

ELAVL2 is involved in various aspects of neuronal function, including neuronal excitability and synaptic transmission . These functions are crucial for normal brain activity, cognition, and behavior. Research has shown that ELAVL2-regulated transcriptional and splicing networks are linked to neurodevelopmental disorders such as autism spectrum disorder (ASD) . Reduced expression of ELAVL2 in human neurons has been associated with altered splicing and differential expression of genes relevant to ASD .

Clinical Relevance

Understanding the role of ELAVL2 in neuronal function and its involvement in neurodevelopmental disorders is essential for developing better diagnostic methods and therapeutic strategies. The protein’s ability to regulate gene expression post-transcriptionally makes it a potential target for interventions aimed at correcting dysregulated gene expression in neurological conditions .

Quick Inquiry

Personal Email Detected
Please use an institutional or corporate email address for inquiries. Personal email accounts ( such as Gmail, Yahoo, and Outlook) are not accepted. *

Category

Service

THE BIOTEK
THE BioTek is a global biotech company offering highly purified proteins for research in cancer, apoptosis, development, endocrinology, immunology, neuroscience, proteases, and stem cells.
  • Contact
  • Address: 1925 E Maple Ave, El Segundo, CA 90245 United States
  • Phone : +1 201-285-7826
  • Email : info@thebiotek.com
  • Hours : Mon.-Fri. 9:00 AM - 5:00 PM
© Copyright 2024 Thebiotek. All Rights Reserved.