EIF1B Human
Description
EIF1B Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 133 amino acids (1-113 a.a.) and having a molecular mass of 15kDa. The EIF1B is purified by proprietary chromatographic techniques.
Product Specs
MGSSHHHHHH SSGLVPRGSH MSTIQNLQSF DPFADATKGD DLLPAGTEDY IHIRIQQRNG RKTLTTVQGI ADDYDKKKLV KAFKKKFACN GTVIEHPEYG EVIQLQGDQR KNICQFLLEV GIVKEEQLKV HGF.
Product Science Overview
Eukaryotic Translation Initiation Factor 1B (EIF1B) is a protein-coding gene that plays a crucial role in the initiation of translation in eukaryotic cells. This factor is essential for the proper assembly of the translation initiation complex, which is necessary for the accurate and efficient synthesis of proteins.
The EIF1B gene is located on chromosome 3 and encodes a protein that is involved in the binding of RNA and the initiation of translation . The protein is a part of the eukaryotic 43S preinitiation complex, which is responsible for the recognition of the start codon on mRNA and the assembly of the ribosome .
EIF1B is predicted to be involved in the early stages of translation initiation. It enables RNA binding activity and is a crucial component of the translation initiation machinery . The protein interacts with other initiation factors to form a stable complex that facilitates the recruitment of the ribosome to the mRNA .
Human recombinant EIF1B is used in various research applications to study the mechanisms of translation initiation and the role of initiation factors in protein synthesis. Recombinant proteins are produced using recombinant DNA technology, which involves inserting the gene encoding EIF1B into an expression vector and introducing it into a host cell to produce the protein.
